Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MMP3_HUMAN
Description:matrix metallopeptidase 3 (stromelysin 1, progelatinase) [Source:HGNC Symbol;Acc:7173]
Location:chr11 q22.2
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y42YLENYyDLKKDPG_binding_1PhosphoSitePlus
Y116KTHLTyRIVNYPeptidase_M10PhosphoSitePlus
Y121YRIVNyTPDLPPeptidase_M10PhosphoSitePlus
Y18AVCSAyPLDGAPhosphoSitePlus
Y41KYLENyYDLKKPG_binding_1PhosphoSitePlus
Y37NLVQKyLENYYPG_binding_1PhosphoSitePlus

Dephosphorylation site
MMP3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000299855R316CCOSMICOvarian Cancer21720365
ENSP00000299855S269FCOSMICSkin Cancer21984974
ENSP00000299855A157GCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000299855Breast CancerNormal vs. Cancercell lineDown0.06219053080

Hyperphosphorylation site
MMP3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ETV4_HUMANMMP3_HUMANTF -> target geneTRANSFAC
ZN148_HUMANMMP3_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
MMP3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004222metalloendopeptidase activityIEAmolecular_function
GO:0030334regulation of cell migrationIEAbiological_process
GO:0008237metallopeptidase activityIEAmolecular_function
GO:0005578proteinaceous extracellular matrixIEAcellular_component
GO:0005576extracellular regionTAScellular_component
GO:0071230cellular response to amino acid stimulusIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0031012extracellular matrixIEAcellular_component
GO:0030574collagen catabolic processIEAbiological_process
GO:0006508proteolysisIEAbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0005615extracellular spaceTAScellular_component
GO:0022617extracellular matrix disassemblyTASbiological_process
GO:0030198extracellular matrix organizationTASbiological_process


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