Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PERE_HUMAN
Description:eosinophil peroxidase [Source:HGNC Symbol;Acc:3423]
Location:chr17 q22
Node attribute:ligand; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S672SRISLsRIICDAn_peroxidasePhosphoSitePlus
S74PMDLLsYFKQPPhosphoSitePlus
Y431VQIITyRDFLPAn_peroxidasePhosphoSitePlus
S322SEVSLsLRLRNAn_peroxidasePhosphoSitePlus
S66RLRSGsASPMDPhosphoSitePlus
Y75MDLLSyFKQPVPhosphoSitePlus
S670ALSRIsLSRIIAn_peroxidasePhosphoSitePlus

Dephosphorylation site
PERE_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000225371R645*COSMICOvarian Cancer21720365
ENSP00000225371Q339EBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000225371Q662KTCGAOvarian Cancer21720365, 18772890
ENSP00000225371S365LCOSMICHead and Neck Cancer21798893
ENSP00000225371R645*TCGAOvarian Cancer21720365, 18772890
ENSP00000225371Q662KCOSMICOvarian Cancer21720365

Differential expressed protein
PERE_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PERE_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PERE_HUMANEPOR_HUMANligand -> receptorHPMR
PERE_HUMANEPOR_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05310Asthma

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0072677eosinophil migrationIEAbiological_process
GO:0032714negative regulation of interleukin-5 productionIEAbiological_process
GO:0006979response to oxidative stressIEAbiological_process
GO:0032753positive regulation of interleukin-4 productionIEAbiological_process
GO:0020037heme bindingIEAmolecular_function
GO:0002215defense response to nematodeIEAbiological_process
GO:0032693negative regulation of interleukin-10 productionIEAbiological_process
GO:0055114oxidation-reduction processIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0004601peroxidase activityIEAmolecular_function
GO:0042744hydrogen peroxide catabolic processIEAbiological_process


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