| UniProt/SwissProt ID: | EDAR_HUMAN |
| Description: | ectodysplasin A receptor [Source:HGNC Symbol;Acc:2895] |
| Location: | chr2 q12.3 |
| Node attribute: | receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S357 | CLEKTsRMLSS | PhosphoSitePlus | |
| S366 | SSTYNsEKAVV | PhosphoSitePlus | |
| Y364 | MLSSTyNSEKA | PhosphoSitePlus | |
| S153 | CVGATsGASAN | PhosphoSitePlus | |
| S324 | SAGIQsRRKKI | HPRD; phosphoELM | |
| S361 | TSRMLsSTYNS | PhosphoSitePlus | |
| S407 | STAGYsIPELL | Death | PhosphoSitePlus |
| T363 | RMLSStYNSEK | PhosphoSitePlus | |
| Dephosphorylation site |
| EDAR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000258443 | R98Q | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| EDAR_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| EDAR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| EDA_HUMAN | EDAR_HUMAN | ligand -> receptor | HPMR |
| EDA_HUMAN | EDAR_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04060 | Cytokine-cytokine receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0008544 | epidermis development | TAS | biological_process |
| GO:0030154 | cell differentiation | IEA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0043473 | pigmentation | IEA | biological_process |
| GO:0042346 | positive regulation of NF-kappaB import into nucle | IEA | biological_process |
| GO:0016021 | integral to membrane | NAS | cellular_component |
| GO:0042475 | odontogenesis of dentin-containing tooth | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0045177 | apical part of cell | IEA | cellular_component |
| GO:0001942 | hair follicle development | IEA | biological_process |
| GO:0060662 | salivary gland cavitation | IEA | biological_process |
| GO:0004888 | transmembrane signaling receptor activity | NAS | molecular_function |
| GO:0004872 | receptor activity | IDA | molecular_function |