Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TNR27_HUMAN
Description:ectodysplasin A2 receptor [Source:HGNC Symbol;Acc:17756]
Location:chrX q12
Node attribute:receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T278TLGGNtVESTGPhosphoSitePlus

Dephosphorylation site
TNR27_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000379365E7QCOSMICHead and Neck Cancer
ENSP00000363851E7QCOSMICHead and Neck Cancer
ENSP00000393935E7QCOSMICHead and Neck Cancer

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000379365Lung CancerNormal vs. CancertissueUp12943690
ENSP00000379365Lung CancerNormal vs. CancertissueUp15626334

Hyperphosphorylation site
TNR27_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
EDA_HUMANTNR27_HUMANligand -> receptorHPMR
EDA_HUMANTNR27_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04060Cytokine-cytokine receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0033209tumor necrosis factor-mediated signaling pathwayNASbiological_process
GO:0005887integral to plasma membraneIEAcellular_component
GO:0046330positive regulation of JNK cascadeIDAbiological_process
GO:0008544epidermis developmentNASbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIDAbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0016021integral to membraneICcellular_component
GO:0009790embryo developmentNASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005031tumor necrosis factor-activated receptor activityNASmolecular_function
GO:0004872receptor activityIDAmolecular_function


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