| UniProt/SwissProt ID: | TNR27_HUMAN |
| Description: | ectodysplasin A2 receptor [Source:HGNC Symbol;Acc:17756] |
| Location: | chrX q12 |
| Node attribute: | receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T278 | TLGGNtVESTG | PhosphoSitePlus | |
| Dephosphorylation site |
| TNR27_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000379365 | E7Q | COSMIC | Head and Neck Cancer | ENSP00000363851 | E7Q | COSMIC | Head and Neck Cancer | ENSP00000393935 | E7Q | COSMIC | Head and Neck Cancer |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000379365 | Lung Cancer | Normal vs. Cancer | tissue | Up | 12943690 | ENSP00000379365 | Lung Cancer | Normal vs. Cancer | tissue | Up | 15626334 |
| Hyperphosphorylation site |
| TNR27_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| EDA_HUMAN | TNR27_HUMAN | ligand -> receptor | HPMR |
| EDA_HUMAN | TNR27_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04060 | Cytokine-cytokine receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0033209 | tumor necrosis factor-mediated signaling pathway | NAS | biological_process |
| GO:0005887 | integral to plasma membrane | IEA | cellular_component |
| GO:0046330 | positive regulation of JNK cascade | IDA | biological_process |
| GO:0008544 | epidermis development | NAS | biological_process |
| GO:0051092 | positive regulation of NF-kappaB transcription fac | IDA | biological_process |
| GO:0030154 | cell differentiation | IEA | biological_process |
| GO:0016021 | integral to membrane | IC | cellular_component |
| GO:0009790 | embryo development | NAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005031 | tumor necrosis factor-activated receptor activity | NAS | molecular_function |
| GO:0004872 | receptor activity | IDA | molecular_function |