| UniProt/SwissProt ID: | RFX4_HUMAN |
| Description: | regulatory factor X, 4 (influences HLA class II expression) [Source:HGNC Symbol;Acc:9985] |
| Location: | chr12 q23.3 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S653 | FNSPTsRMEPC | PhosphoSitePlus | |
| Y129 | QSKYHyYGIAV | RFX_DNA_binding | PhosphoSitePlus |
| Y140 | KESSQyYDVMY | PhosphoSitePlus | |
| S40 | SLGNVsNDENE | PhosphoSitePlus | |
| Y168 | KQTVAySPRSK | PhosphoSitePlus | |
| Y364 | TKQTLyTMEDS | PhosphoSitePlus | |
| Y127 | RGQSKyHYYGI | RFX_DNA_binding | PhosphoSitePlus |
| T215 | QRILDtVIRAN | PhosphoSitePlus | |
| S325 | LRRQTsLNHLC | PhosphoSitePlus | |
| S333 | HLCQAsRTVIH | PhosphoSitePlus | |
| Y130 | SKYHYyGIAVK | RFX_DNA_binding | PhosphoSitePlus |
| Dephosphorylation site |
| RFX4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000350552 | S366N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000229387 | D533Y | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000350552 | D636Y | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000376585 | S357N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000229387 | C339R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000350552 | C442R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000376585 | D627Y | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000229387 | S263N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000376585 | C433R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000376585 | H386N | COSMIC | Head and Neck Cancer | 21798897 |
| Differential expressed protein |
| RFX4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RFX4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| RFX4_HUMAN | IL5RA_HUMAN | TF -> target gene | TRANSFAC |
| RFX4_HUMAN | DRA_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| RFX4_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006357 | regulation of transcription from RNA polymerase II | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0021516 | dorsal spinal cord development | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0003682 | chromatin binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0030900 | forebrain development | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0021696 | cerebellar cortex morphogenesis | IEA | biological_process |
| GO:0030901 | midbrain development | IEA | biological_process |