| UniProt/SwissProt ID: | RFX2_HUMAN |
| Description: | regulatory factor X, 2 (influences HLA class II expression) [Source:HGNC Symbol;Acc:9983] |
| Location: | chr19 p13.3 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y221 | PRSSLyNHYLR | RFX_DNA_binding | PhosphoSitePlus |
| S219 | SLPRSsLYNHY | RFX_DNA_binding | PhosphoSitePlus |
| Y108 | SSTASyFEAPG | RFX1_trans_act | PhosphoSitePlus |
| Y224 | SLYNHyLRHCQ | RFX_DNA_binding | PhosphoSitePlus |
| Y93 | RTAYTyNPEPQ | RFX1_trans_act | PhosphoSitePlus |
| Y287 | QEDTQyMAMRQ | PhosphoSitePlus | |
| Y100 | PEPQMyAPSST | RFX1_trans_act | PhosphoSitePlus |
| Y82 | GGDAVyTNGAI | RFX1_trans_act | PhosphoSitePlus |
| S719 | SDPNHsLQGI_ | PhosphoSitePlus | |
| Dephosphorylation site |
| RFX2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000306335 | V549L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000306335 | E110K | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 | ENSP00000306335 | T189S | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000306335 | A37G | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 |
| Differential expressed protein |
| RFX2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RFX2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| RFX2_HUMAN | IL5RA_HUMAN | TF -> target gene | TRANSFAC |
| RFX2_HUMAN | DRA_HUMAN | TF -> target gene | TRANSFAC |
| RFX2_HUMAN | DQB1_HUMAN | TF -> target gene | TRANSFAC |
| RFX2_HUMAN | DPA1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| RFX2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |