| UniProt/SwissProt ID: | DRA_HUMAN |
| Description: | major histocompatibility complex, class II, DR alpha [Source:HGNC Symbol;Acc:4947] |
| Location: | chrHSCHR6_MHC_COX p2 |
| Node attribute: | gene |
| Phosphorylation site |
| DRA_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| DRA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000378786 | M98I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000378786 | E113K | COSMIC | Melanoma | 21499247 | ENSP00000378786 | E216* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000378786 | E197D | COSMIC | Skin Cancer | 21984974 | ENSP00000378786 | G150R | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000372746 | Oral Cancer | Normal vs. Cancer | tissue | Up | 5 | 19297561 | ENSP00000372746 | Breast Cancer | Metastasis | cell line | Up | >5 | 19321434 | ENSP00000372746 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.18 | 20198662 |
| Hyperphosphorylation site |
| DRA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| XBP1_HUMAN | DRA_HUMAN | TF -> target gene | TRANSFAC |
| RFX2_HUMAN | DRA_HUMAN | TF -> target gene | TRANSFAC |
| RFX4_HUMAN | DRA_HUMAN | TF -> target gene | TRANSFAC |
| RFX3_HUMAN | DRA_HUMAN | TF -> target gene | TRANSFAC |
| FOS_HUMAN | DRA_HUMAN | TF -> target gene | TRANSFAC |
| CREB1_HUMAN | DRA_HUMAN | TF -> target gene | TRANSFAC |
| RFX1_HUMAN | DRA_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| DRA_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0012507 | ER to Golgi transport vesicle membrane | TAS | cellular_component |
| GO:0031295 | T cell costimulation | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0030658 | transport vesicle membrane | TAS | cellular_component |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0006955 | immune response | IEA | biological_process |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0019882 | antigen processing and presentation | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | NAS | cellular_component |
| GO:0060333 | interferon-gamma-mediated signaling pathway | TAS | biological_process |
| GO:0006955 | immune response | NAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0002504 | antigen processing and presentation of peptide or | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0030669 | clathrin-coated endocytic vesicle membrane | TAS | cellular_component |
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0032395 | MHC class II receptor activity | NAS | molecular_function |
| GO:0030666 | endocytic vesicle membrane | TAS | cellular_component |
| GO:0032588 | trans-Golgi network membrane | TAS | cellular_component |
| GO:0005764 | lysosome | IDA | cellular_component |
| GO:0042613 | MHC class II protein complex | IEA | cellular_component |
| GO:0071556 | integral to lumenal side of endoplasmic reticulum | TAS | cellular_component |
| GO:0031902 | late endosome membrane | IDA | cellular_component |
| GO:0019886 | antigen processing and presentation of exogenous p | TAS | biological_process |
| GO:0050852 | T cell receptor signaling pathway | TAS | biological_process |
| GO:0005765 | lysosomal membrane | IDA | cellular_component |