| UniProt/SwissProt ID: | NTKL_HUMAN |
| Description: | SCY1-like 1 (S. cerevisiae) [Source:HGNC Symbol;Acc:14372] |
| Location: | chr11 q13.1 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S638 | DTAEDsSTADR | PhosphoSitePlus | |
| S681 | SQVSNsDHKSS | PhosphoSitePlus; HPRD | |
| S664 | SQVSNsDHKSS | HPRD | |
| Y725 | RLASEyNWGGP | PhosphoSitePlus | |
| T741 | GDPFAtLSARP | PhosphoSitePlus | |
| S558 | DVHAAsSPGMG | HPRD; SysPTM | |
| T634 | EEDKDtAEDSS | PhosphoSitePlus | |
| S747 | LSARPsTQPRP | PhosphoSitePlus | |
| T640 | AEDSStADRWD | PhosphoSitePlus | |
| S639 | TAEDSsTADRW | PhosphoSitePlus | |
| S754 | QPRPDsWGEDN | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T332 | GAVVLtPLFKV | PhosphoSitePlus | |
| S737 | QPRPDsWGEDN | HPRD | |
| S568 | GGAAAsWAGWA | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| NTKL_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000270176 | H495Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000408192 | E673G | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000408192 | H495Q | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000270176 | E690G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000270176 | H495Y | Greenman2007 | Skin Cancer | 17344846, 18428421 |
| Differential expressed protein |
| NTKL_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NTKL_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NTKL_HUMAN | CSRP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NTKL_HUMAN | DGCR8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| NTKL_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | NAS | molecular_function |
| GO:0005815 | microtubule organizing center | IEA | cellular_component |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0005488 | binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0005793 | endoplasmic reticulum-Golgi intermediate compartme | IDA | cellular_component |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0030126 | COPI vesicle coat | IEA | cellular_component |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0030126 | COPI vesicle coat | IDA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | IDA | biological_process |
| GO:0005801 | cis-Golgi network | IDA | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |