| UniProt/SwissProt ID: | DGCR8_HUMAN |
| Description: | DiGeorge syndrome critical region gene 8 [Source:HGNC Symbol;Acc:2847] |
| Location: | chr22 q11.21 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S271 | KYGGDsDHPSD | PhosphoSitePlus; HPRD; phosphoELM | |
| Y267 | RTEEKyGGDSD | PhosphoSitePlus; HPRD; phosphoELM | |
| S8 | TDESPsPLPCG | PhosphoSitePlus | |
| T371 | QSSDLtPSGDV | PhosphoSitePlus | |
| S92 | IDPNCsGHSPR | PhosphoSitePlus; HPRD; phosphoELM | |
| S377 | PSGDVsPVKPL | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S545 | EPFGAsVTIDG | dsrm; PEGA | PhosphoSitePlus |
| S95 | NCSGHsPRTAR | PhosphoSitePlus; HPRD; phosphoELM | |
| S383 | PVKPLsRSAEL | HPRD; SysPTM | |
| S109 | AVRKFsPDLKL | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T547 | FGASVtIDGVT | dsrm; PEGA | PhosphoSitePlus |
| S280 | SDGETsVQPMM | PhosphoSitePlus | |
| S373 | SDLTPsGDVSP | PhosphoSitePlus; HPRD | |
| T279 | PSDGEtSVQPM | HPRD; phosphoELM | |
| S275 | DSDHPsDGETS | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| DGCR8_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000263209 | E214K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000384726 | E141Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000372488 | E141Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000263209 | E141Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000372488 | E214K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000372488 | E47Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000384726 | E47Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000384726 | E214K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000263209 | E47Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000263209 | S44G | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| DGCR8_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DGCR8_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDKL5_HUMAN | DGCR8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | DGCR8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NTKL_HUMAN | DGCR8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | DGCR8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| DGCR8_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0003725 | double-stranded RNA binding | IDA | molecular_function |
| GO:0031053 | primary miRNA processing | IDA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0015630 | microtubule cytoskeleton | IDA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0010467 | gene expression | TAS | biological_process |