UniProt/SwissProt ID: | DCLK1_HUMAN |
Description: | doublecortin-like kinase 1 [Source:HGNC Symbol;Acc:2700] |
Location: | chr13 q13.3 |
Node attribute: | kinase |
Phosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
S330 | PRSGKsPSPSP | PhosphoSitePlus; HPRD | |
S337 | SPSPTsPGSLR | PhosphoSitePlus; HPRD | |
S738 | VRSPNsPF___ | PhosphoSitePlus | |
S334 | KSPSPsPTSPG | PhosphoSitePlus; HPRD | |
S353 | QHGGSsTSLAS | PhosphoSitePlus | |
S327 | LSTPRsGKSPS | PhosphoSitePlus | |
S32 | VNGLPsPTHSA | PhosphoSitePlus | |
S332 | SGKSPsPSPTS | PhosphoSitePlus; HPRD | |
S729 | DYSPSsSETVR | PhosphoSitePlus | |
S313 | PASTSsVNGTP | PhosphoSitePlus | |
S305 | GPSRRsKSPAS | PhosphoSitePlus | |
S312 | SPASTsSVNGT | PhosphoSitePlus | |
S274 | FLLDEsECRVV | PhosphoSitePlus | |
T324 | GSQLStPRSGK | PhosphoSitePlus | |
T336 | PSPSPtSPGSL | PhosphoSitePlus; HPRD | |
T46 | FYRTRtLQTLS | PhosphoSitePlus | |
T34 | GLPSPtHSAHC | PhosphoSitePlus | |
S164 | ASRAVsSLATA | PhosphoSitePlus | |
Y265 | PEKFRyQDDFL | PhosphoSitePlus | |
S352 | SQHGGsSTSLA | PhosphoSitePlus; HPRD | |
S340 | PTSPGsLRKQR | PhosphoSitePlus | |
S307 | SRRSKsPASTS | PhosphoSitePlus | |
Dephosphorylation site |
DCLK1_HUMAN do not have dephosphorylation site. |
Mutation site |
Ensembl ID | Variation | Source | Cancer name | Pubmed |
---|---|---|---|---|
ENSP00000353846 | R93Q | Greenman2007, HPI | Gastric Cancer | 17344846 |
ENSP00000255448 | T46M | Greenman2007 | Gastric Cancer | 17344846 |
ENSP00000255448 | *730Y | COSMIC | Lung Cancer | 18948947 |
ENSP00000369223 | *434Y | COSMIC | Ovarian Cancer | 20826764 |
ENSP00000255448 | R93Q | Greenman2007 | Gastric Cancer | 17344846 |
ENSP00000353846 | R82L | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000353846 | S291F | Greenman2007, HPI | Gastric Cancer | 17344846 |
ENSP00000255448 | S291F | Greenman2007 | Gastric Cancer | 17344846 |
ENSP00000255448 | R82L | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000255448 | G29C | Greenman2007 | Gastric Cancer | 17344846 |
ENSP00000353846 | T46M | Greenman2007, HPI | Gastric Cancer | 17344846 |
ENSP00000353846 | G29C | Greenman2007, HPI | Gastric Cancer | 17344846 |
Differential expressed protein |
DCLK1_HUMAN is not differential expressed protein. |
Hyperphosphorylation site |
DCLK1_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Source | Target | Relationship | Resource |
---|---|---|---|
DCLK1_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
DCLK1_HUMAN | MK01_HUMAN | kinase -> substrate | Robert H Newman (2013) |
DCLK1_HUMAN | KAPCB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
Function Annotation |
KEGG Pathway |
DCLK1_HUMAN is not in KEGG pathway. |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0007420 | brain development | IEA | biological_process |
GO:0005057 | receptor signaling protein activity | TAS | molecular_function |
GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
GO:0007399 | nervous system development | TAS | biological_process |
GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
GO:0035556 | intracellular signal transduction | IEA | biological_process |
GO:0007409 | axonogenesis | IEA | biological_process |
GO:0048675 | axon extension | IEA | biological_process |
GO:0030900 | forebrain development | IEA | biological_process |
GO:0005887 | integral to plasma membrane | TAS | cellular_component |
GO:0006468 | protein phosphorylation | TAS | biological_process |
GO:0009615 | response to virus | IEP | biological_process |
GO:0048813 | dendrite morphogenesis | IEA | biological_process |
GO:0004672 | protein kinase activity | TAS | molecular_function |
GO:0016197 | endosomal transport | NAS | biological_process |
GO:0005524 | ATP binding | IEA | molecular_function |
GO:0004672 | protein kinase activity | IEA | molecular_function |
GO:0021952 | central nervous system projection neuron axonogene | IEA | biological_process |
GO:0006468 | protein phosphorylation | IEA | biological_process |
GO:0007417 | central nervous system development | TAS | biological_process |
GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
GO:0001764 | neuron migration | IEA | biological_process |