Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CDN1B_HUMAN
Description:cyclin-dependent kinase inhibitor 1B (p27, Kip1) [Source:HGNC Symbol;Acc:1785]
Location:chr12 p13.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y74PLEGKyEWQEVYES1HPRD
T198LRRRQtRSK2RegPhos
S178NVSDGsPNAGSMAPK1phosphoELM
S10RVSNGsPSLERCDK2RegPhos
T198LRRRRSK-2phosphoELM
Y74PLEGKyEWQEVphosphoELM
Y88SLPEFyYRPPRABL1HPRD; RegPhos
T198LRRRHPRD; phosphoELM
S183SPNAGsVEQTPPhosphoSitePlus
T187GSVEQtPKKPGPhosphoSitePlus; HPRD; phosphoELM
Y88SLPEFyYRPPRLYNHPRD; RegPhos
T198LRRRRSK_groupphosphoELM
Y89LPEFYyRPPRPSRCphosphoELM
T157RKRPAtDDSSTAKT_groupRegPhos
T157RKRPAtDDSSTAKT1HPRD; RegPhos
T198LRRRQtAKT_groupRegPhos
T198LRRRQt_____PhosphoSitePlus
S10RVSNGsPSLERPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y88SLPEFyYRPPRSRCHPRD; phosphoELM
Y88SLPEFyYRPPRYES1HPRD
Y74PLEGKyEWQEVSRCHPRD; phosphoELM
T157RKRPAtDDSSTPKB_groupphosphoELM
S178NVSDGsPNAGSErk2(MAPK1RegPhos
T187GSVEQtPKKPGCDK2HPRD; phosphoELM; RegPhos
Y74PLEGKyEWQEVCDIPhosphoSitePlus
Y89LPEFYyRPPRPPhosphoSitePlus; phosphoELM; RegPhos
S83EVEKGsLPEFYCK2a1(CK2 alphaRegPhos
S83EVEKGsLPEFYPhosphoSitePlus; phosphoELM
T157RKRPAtDDSSTPhosphoSitePlus
Y88SLPEFyYRPPRPhosphoSitePlus; phosphoELM; RegPhos
S10RVSNGsPSLERKISphosphoELM; RegPhos
T198LRRRQtRSK_groupRegPhos
S140TDPSDsQTGLAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T187GSVEQtPKKPGErk2(MAPK1RegPhos
S10RVSNGsPSLERPKB_groupphosphoELM
S178NVSDGsPNAGSPhosphoSitePlus; phosphoELM

Dephosphorylation site
CDN1B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000228872E78KCOSMICOvarian Cancer21720365
ENSP00000228872M52ICOSMICLung Cancer20668451

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000228872Breast CancerNormal vs. Cancercell lineUp1.620052998
ENSP00000228872Breast CancerNormal vs. Cancercell lineUp3.420052998
ENSP00000228872Breast CancerMetastasiscell lineUp2.120052998

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
T157GIRKRPAtDDSSTQNpapillary thyroid carcinoma; follicular thyroid carcinoma; anaplastic thyroid carcinoma15743786PhosphoSitePlus
T198PGLRRRQt_______papillary thyroid carcinoma; follicular thyroid carcinoma; anaplastic thyroid carcinoma15743786PhosphoSitePlus
Y74CDIHKPLEGKyEWQEVEKbreast cancer17254967PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANCDN1B_HUMANkinase -> substrateRegPhos
CDK2_HUMANCDN1B_HUMANkinase -> substrateRegPhos
SRC_HUMANCDN1B_HUMANkinase -> substrateHPRD
LYN_HUMANCDN1B_HUMANkinase -> substrateHPRD; RegPhos
CSK21_HUMANCDN1B_HUMANkinase -> substrateRobert H Newman (2013)
UHMK1_HUMANCDN1B_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
YES_HUMANCDN1B_HUMANkinase -> substrateHPRD
AKT1_HUMANCDN1B_HUMANkinase -> substrateHPRD; RegPhos
KS6A3_HUMANCDN1B_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK01_HUMANCDN1B_HUMANkinase -> substrateRobert H Newman (2013)
ABL1_HUMANCDN1B_HUMANkinase -> substrateHPRD; RegPhos
AKT3_HUMANCDN1B_HUMANkinase -> substrateKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05203Viral carcinogenesis
hsa04110Cell cycle
hsa05215Prostate cancer
hsa05162Measles
hsa05200Pathways in cancer
hsa04012ErbB signaling pathway
hsa05202Transcriptional misregulation in cancer
hsa05222Small cell lung cancer
hsa05220Chronic myeloid leukemia
hsa05169Epstein-Barr virus infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0033673negative regulation of kinase activityIDAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0008656cysteine-type endopeptidase activator activity invIDAmolecular_function
GO:0071236cellular response to antibioticIEAbiological_process
GO:0006813potassium ion transportIEAbiological_process
GO:0006919activation of cysteine-type endopeptidase activityIDAbiological_process
GO:0000082G1/S transition of mitotic cell cycleIDAbiological_process
GO:0005768endosomeIEAcellular_component
GO:0019903protein phosphatase bindingIPImolecular_function
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0031116positive regulation of microtubule polymerizationIEAbiological_process
GO:0000079regulation of cyclin-dependent protein kinase actiTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0050680negative regulation of epithelial cell proliferatiIEAbiological_process
GO:0060770negative regulation of epithelial cell proliferatiIEAbiological_process
GO:0030308negative regulation of cell growthIDAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0048839inner ear developmentIEAbiological_process
GO:0071407cellular response to organic cyclic compoundIEAbiological_process
GO:0010942positive regulation of cell deathIDAbiological_process
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0007050cell cycle arrestIMPbiological_process
GO:0004861cyclin-dependent protein kinase inhibitor activityIEAmolecular_function
GO:0045736negative regulation of cyclin-dependent protein kiIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0000080G1 phase of mitotic cell cycleTASbiological_process
GO:0071850mitotic cell cycle arrestIDAbiological_process
GO:0005829cytosolTAScellular_component
GO:0007605sensory perception of soundIEAbiological_process
GO:0006917induction of apoptosisIDAbiological_process
GO:0051271negative regulation of cellular component movementIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0000082G1/S transition of mitotic cell cycleIEAbiological_process
GO:0045732positive regulation of protein catabolic processIDAbiological_process
GO:0006977DNA damage response, signal transduction by p53 clTASbiological_process
GO:0048102autophagic cell deathIDAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0000075cell cycle checkpointTASbiological_process
GO:0045930negative regulation of mitotic cell cycleIDAbiological_process
GO:0008285negative regulation of cell proliferationIDAbiological_process
GO:0042326negative regulation of phosphorylationIDAbiological_process
GO:0071285cellular response to lithium ionIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005072transforming growth factor beta receptor, cytoplasTASmolecular_function
GO:0007050cell cycle arrestIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process