Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CD86_HUMAN
Description:CD86 molecule [Source:HGNC Symbol;Acc:1705]
Location:chr3 q13.33
Node attribute:PPI(source); gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y108KDKGLyQCIIHV-setPhosphoSitePlus

Dephosphorylation site
CD86_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000332049W268*COSMICMelanoma21499247
ENSP00000332049K188ECOSMICPancreatic Cancer
ENSP00000332049N135HCOSMICOvarian Cancer21720365
ENSP00000332049L63VCOSMICOvarian Cancer21720365

Differential expressed protein
CD86_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CD86_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CD86_HUMANCD28_HUMANotherKEGG
CD86_HUMANCTLA4_HUMANotherKEGG
IRF3_HUMANCD86_HUMANTF -> target geneKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05202Transcriptional misregulation in cancer
hsa05320Autoimmune thyroid disease
hsa04672Intestinal immune network for IgA production
hsa05322Systemic lupus erythematosus
hsa04940Type I diabetes mellitus
hsa04514Cell adhesion molecules (CAMs)
hsa04620Toll-like receptor signaling pathway
hsa05330Allograft rejection
hsa05416Viral myocarditis
hsa05323Rheumatoid arthritis
hsa05332Graft-versus-host disease

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051607defense response to virusIEAbiological_process
GO:0008284positive regulation of cell proliferationTASbiological_process
GO:0004872receptor activityTASmolecular_function
GO:0045630positive regulation of T-helper 2 cell differentiaNASbiological_process
GO:0006955immune responseTASbiological_process
GO:0043017positive regulation of lymphotoxin A biosynthetic NASbiological_process
GO:0042110T cell activationICbiological_process
GO:0045893positive regulation of transcription, DNA-dependenNASbiological_process
GO:0045404positive regulation of interleukin-4 biosynthetic NASbiological_process
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0042113B cell activationIEAbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0015026coreceptor activityNASmolecular_function
GO:0007267cell-cell signalingICbiological_process
GO:0016021integral to membraneICcellular_component
GO:0045086positive regulation of interleukin-2 biosynthetic NASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0002224toll-like receptor signaling pathwayIEAbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0031295T cell costimulationTASbiological_process


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