| UniProt/SwissProt ID: | CD80_HUMAN |
| Description: | CD80 molecule [Source:HGNC Symbol;Acc:1700] |
| Location: | chr3 q13.33 |
| Node attribute: | PPI(target); PPI(source); gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S284 | RLRREsVRPV_ | PhosphoSitePlus | |
| Dephosphorylation site |
| CD80_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000264246 | V225E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000264246 | E86K | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000264246 | S165F | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000418364 | S165F | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000264246 | F19L | COSMIC | Head and Neck Cancer | 21798897 |
| Differential expressed protein |
| CD80_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CD80_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CD80_HUMAN | CD28_HUMAN | other | KEGG |
| CD28_HUMAN | CD80_HUMAN | other | KEGG |
| CD80_HUMAN | CTLA4_HUMAN | other | KEGG |
| IRF3_HUMAN | CD80_HUMAN | TF -> target gene | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04672 | Intestinal immune network for IgA production |
| hsa04940 | Type I diabetes mellitus |
| hsa05330 | Allograft rejection |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa05320 | Autoimmune thyroid disease |
| hsa05332 | Graft-versus-host disease |
| hsa04514 | Cell adhesion molecules (CAMs) |
| hsa05323 | Rheumatoid arthritis |
| hsa05416 | Viral myocarditis |
| hsa05322 | Systemic lupus erythematosus |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016021 | integral to membrane | IC | cellular_component |
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0035556 | intracellular signal transduction | NAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0045627 | positive regulation of T-helper 1 cell differentia | NAS | biological_process |
| GO:0015026 | coreceptor activity | NAS | molecular_function |
| GO:0031295 | T cell costimulation | IEA | biological_process |
| GO:0042110 | T cell activation | IC | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0045086 | positive regulation of interleukin-2 biosynthetic | NAS | biological_process |
| GO:0045425 | positive regulation of granulocyte macrophage colo | NAS | biological_process |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphory | IDA | biological_process |
| GO:0031295 | T cell costimulation | TAS | biological_process |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0046641 | positive regulation of alpha-beta T cell prolifera | IEA | biological_process |
| GO:0009967 | positive regulation of signal transduction | NAS | biological_process |
| GO:0007267 | cell-cell signaling | IC | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | NAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |