| UniProt/SwissProt ID: | CD5_HUMAN |
| Description: | CD5 molecule [Source:HGNC Symbol;Acc:1685] |
| Location: | chr11 q12.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S485 | DNSSDsDYDLH | CSNK2A1 | HPRD |
| S482 | MQPDNsSDSDY | CK2a1 | RegPhos |
| S483 | QPDNSsDSDYD | CSNK2A1 | HPRD |
| S485 | DNSSDsDYDLH | CK2_alpha | phosphoELM |
| S485 | DNSSDsDYDLH | CK2a1-rs | RegPhos |
| S482 | MQPDNsSDSDY | PhosphoSitePlus | |
| Y453 | HVDNEySQPPR | Lck | phosphoELM; RegPhos |
| S483 | QPDNSsDSDYD | PhosphoSitePlus | |
| Y453 | HVDNEySQPPR | LCK | HPRD; RegPhos |
| T436 | RNHTAtVRSHA | PRKCG | HPRD |
| T436 | RNHTAtVRSHA | PRKCB | HPRD |
| T436 | RNHTAtVRSHA | PRKCA | HPRD |
| S439 | TATVRsHAENP | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| T436 | RNHTAtVRSHA | PKCb | RegPhos |
| Y487 | SSDSDyDLHGA | Lck | phosphoELM; RegPhos |
| S454 | VDNEYsQPPRN | PhosphoSitePlus; HPRD; RegPhos | |
| S483 | QPDNSsDSDYD | CK2_alpha | phosphoELM |
| T436 | RNHTAtVRSHA | PKCa(PKC alpha | RegPhos |
| T434 | FHRNHtATVRS | PKC_alpha | phosphoELM |
| S428 | MNQNMsFHRNH | PhosphoSitePlus | |
| T434 | FHRNHtATVRS | PhosphoSitePlus | |
| T436 | RNHTAtVRSHA | PKCa | RegPhos |
| T434 | FHRNHtATVRS | PRKCG | HPRD |
| T434 | FHRNHtATVRS | PRKCB | HPRD |
| T434 | FHRNHtATVRS | PRKCA | HPRD |
| S485 | DNSSDsDYDLH | CK2a1 | RegPhos |
| S483 | QPDNSsDSDYD | CK2a1-rs | RegPhos |
| S482 | MQPDNsSDSDY | CK2a1-rs | RegPhos |
| S460 | QPPRNsHLSAY | PhosphoSitePlus; HPRD | |
| Y487 | SSDSDyDLHGA | FYN | HPRD; RegPhos |
| S482 | MQPDNsSDSDY | CSNK2A1 | HPRD |
| S485 | DNSSDsDYDLH | CK2_group | phosphoELM; RegPhos |
| S483 | QPDNSsDSDYD | CK2_group | phosphoELM; RegPhos |
| S485 | DNSSDsDYDLH | CK2a1(CK2 alpha | RegPhos |
| T434 | FHRNHtATVRS | PKCb | RegPhos |
| T434 | FHRNHtATVRS | PKCa | RegPhos |
| S483 | QPDNSsDSDYD | CK2a1 | RegPhos |
| Y453 | HVDNEySQPPR | PhosphoSitePlus; phosphoELM; RegPhos | |
| S447 | ENPTAsHVDNE | PhosphoSitePlus | |
| Y465 | SRLSAyPALEG | phosphoELM; RegPhos | |
| T434 | FHRNHtATVRS | PKCg | RegPhos |
| T436 | RNHTAtVRSHA | PKCg | RegPhos |
| S485 | DNSSDsDYDLH | PhosphoSitePlus | |
| T434 | FHRNHtATVRS | PKCa(PKC alpha | RegPhos |
| Y465 | SHLSAyPALEG | PhosphoSitePlus; HPRD | |
| Y487 | SSDSDyDLHGA | PhosphoSitePlus | |
| S483 | QPDNSsDSDYD | CK2a1(CK2 alpha | RegPhos |
| S186 | LGGTIsYEAQD | SRCR | PhosphoSitePlus |
| Y453 | HVDNEySQPPR | FYN | HPRD; RegPhos |
| Y487 | SSDSDyDLHGA | LCK | HPRD; RegPhos |
| T436 | RNHTAtVRSHA | PKC_alpha | phosphoELM |
| T445 | HAENPtASHVD | PhosphoSitePlus | |
| S482 | MQPDNsSDSDY | CK2_alpha | phosphoELM |
| S482 | MQPDNsSDSDY | CK2a1(CK2 alpha | RegPhos |
| S482 | MQPDNsSDSDY | CK2_group | phosphoELM; RegPhos |
| T436 | RNHTAtVRSHA | PhosphoSitePlus | |
| S460 | QPPRNsRLSAY | phosphoELM; RegPhos | |
| Dephosphorylation site |
| CD5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000342681 | A306D | COSMIC | Ovarian Cancer | 21720365 | ENSP00000342681 | A306D | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| CD5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CD5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCB_HUMAN | CD5_HUMAN | kinase -> substrate | HPRD |
| LCK_HUMAN | CD5_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| ZAGL2_HUMAN | CD5_HUMAN | kinase -> substrate | RegPhos |
| KPCA_HUMAN | CD5_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| KPCG_HUMAN | CD5_HUMAN | kinase -> substrate | HPRD |
| FYN_HUMAN | CD5_HUMAN | kinase -> substrate | RegPhos |
| CSK21_HUMAN | CD5_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04640 | Hematopoietic cell lineage |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004888 | transmembrane signaling receptor activity | NAS | molecular_function |
| GO:0031295 | T cell costimulation | IEA | biological_process |
| GO:0008037 | cell recognition | NAS | biological_process |
| GO:0008283 | cell proliferation | NAS | biological_process |
| GO:0004872 | receptor activity | NAS | molecular_function |
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005887 | integral to plasma membrane | NAS | cellular_component |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0005044 | scavenger receptor activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |