Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SOX9_HUMAN
Description:SRY (sex determining region Y)-box 9 [Source:HGNC Symbol;Acc:11204]
Location:chr17 q24.3
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S211ALQADsPHSSSHPRD
S181PRRRKsVKNGQPhosphoSitePlus
S64DLKKEsEEDKFPKA_groupphosphoELM
Y172KDHPDyKYQPRHMG_boxPhosphoSitePlus
Y442RSQYDyTDHQNPhosphoSitePlus
T43GSGSDtENTRPSox_NPhosphoSitePlus
S30TMSEDsAGSPCSox_NPhosphoSitePlus
S181PRRRKsVKNGQPKA_groupphosphoELM
S64DLKKEsEEDKFphosphoELM
S64DLKKEsEEDKFSox_NPhosphoSitePlus
T46SDTENtRPQENSox_NPhosphoSitePlus
T11PFMKMtDEQEKPhosphoSitePlus
S181PRRRKsVKNGQROCK1phosphoELM

Dephosphorylation site
SOX9_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000245479P479HBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000245479R264TCOSMICHead and Neck Cancer21798893

Differential expressed protein
SOX9_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SOX9_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AKT1_HUMANSOX9_HUMANkinase -> substrateRobert H Newman (2013)
SOX9_HUMANCD3E_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
SOX9_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0060729intestinal epithelial structure maintenanceISSbiological_process
GO:0001708cell fate specificationISSbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0071260cellular response to mechanical stimulusISSbiological_process
GO:0001942hair follicle developmentISSbiological_process
GO:0035622intrahepatic bile duct developmentIEAbiological_process
GO:0043234protein complexIDAcellular_component
GO:0007173epidermal growth factor receptor signaling pathwayISSbiological_process
GO:0050679positive regulation of epithelial cell proliferatiISSbiological_process
GO:0006338chromatin remodelingIDAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0003179heart valve morphogenesisISSbiological_process
GO:0003203endocardial cushion morphogenesisIEAbiological_process
GO:0042127regulation of cell proliferationISSbiological_process
GO:0032331negative regulation of chondrocyte differentiationISSbiological_process
GO:0061138morphogenesis of a branching epitheliumIEAbiological_process
GO:0090090negative regulation of canonical Wnt receptor signIEAbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayIEAbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaIEAbiological_process
GO:0007283spermatogenesisISSbiological_process
GO:0090184positive regulation of kidney developmentIEAbiological_process
GO:0002053positive regulation of mesenchymal cell proliferatISSbiological_process
GO:0060008Sertoli cell differentiationISSbiological_process
GO:0001837epithelial to mesenchymal transitionIEAbiological_process
GO:0045662negative regulation of myoblast differentiationIEAbiological_process
GO:0003682chromatin bindingIDAmolecular_function
GO:0003203endocardial cushion morphogenesisISSbiological_process
GO:0060221retinal rod cell differentiationISSbiological_process
GO:0050679positive regulation of epithelial cell proliferatiIEAbiological_process
GO:0042981regulation of apoptotic processISSbiological_process
GO:0000976transcription regulatory region sequence-specific IEAmolecular_function
GO:0001894tissue homeostasisISSbiological_process
GO:0035326enhancer bindingIDAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0072197ureter morphogenesisIEAbiological_process
GO:0001942hair follicle developmentIEAbiological_process
GO:0090190positive regulation of branching involved in ureteISSbiological_process
GO:0072289metanephric nephron tubule formationISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0071260cellular response to mechanical stimulusIEAbiological_process
GO:0008284positive regulation of cell proliferationIMPbiological_process
GO:0043491protein kinase B signaling cascadeIEAbiological_process
GO:0060517epithelial cell proliferation involved in prostatiIEAbiological_process
GO:0071300cellular response to retinoic acidIEPbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0031018endocrine pancreas developmentIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0060018astrocyte fate commitmentIEAbiological_process
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0060512prostate gland morphogenesisIEAbiological_process
GO:0045662negative regulation of myoblast differentiationISSbiological_process
GO:0030916otic vesicle formationIEAbiological_process
GO:0030502negative regulation of bone mineralizationIEAbiological_process
GO:0060008Sertoli cell differentiationIEAbiological_process
GO:0043066negative regulation of apoptotic processISSbiological_process
GO:0072034renal vesicle inductionIEAbiological_process
GO:0034236protein kinase A catalytic subunit bindingIPImolecular_function
GO:0030154cell differentiationIEAbiological_process
GO:0019933cAMP-mediated signalingIDAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0001894tissue homeostasisIEAbiological_process
GO:0010634positive regulation of epithelial cell migrationIMPbiological_process
GO:0007165signal transductionISSbiological_process
GO:0045165cell fate commitmentIEAbiological_process
GO:0006461protein complex assemblyIDAbiological_process
GO:2000020positive regulation of male gonad developmentIDAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0002683negative regulation of immune system processIEAbiological_process
GO:0030279negative regulation of ossificationISSbiological_process
GO:0001837epithelial to mesenchymal transitionISSbiological_process
GO:0030850prostate gland developmentIEAbiological_process
GO:0003415chondrocyte hypertrophyISSbiological_process
GO:0061036positive regulation of cartilage developmentIDAbiological_process
GO:0060009Sertoli cell developmentIEAbiological_process
GO:0003179heart valve morphogenesisIEAbiological_process
GO:0060784regulation of cell proliferation involved in tissuISSbiological_process
GO:0090184positive regulation of kidney developmentISSbiological_process
GO:0090103cochlea morphogenesisISSbiological_process
GO:0060729intestinal epithelial structure maintenanceIEAbiological_process
GO:0019100male germ-line sex determinationISSbiological_process
GO:0030916otic vesicle formationISSbiological_process
GO:0003415chondrocyte hypertrophyIEAbiological_process
GO:0008584male gonad developmentIEPbiological_process
GO:0003170heart valve developmentISSbiological_process
GO:0003413chondrocyte differentiation involved in endochondrIMPbiological_process
GO:0007417central nervous system developmentIEAbiological_process
GO:0001158enhancer sequence-specific DNA bindingIEAmolecular_function
GO:0003188heart valve formationIEAbiological_process
GO:0050680negative regulation of epithelial cell proliferatiIEAbiological_process
GO:0046533negative regulation of photoreceptor cell differenIEAbiological_process
GO:0002062chondrocyte differentiationIEAbiological_process
GO:0001077RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0030858positive regulation of epithelial cell differentiaISSbiological_process
GO:0004672protein kinase activityISSmolecular_function
GO:0071364cellular response to epidermal growth factor stimuIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0071504cellular response to heparinISSbiological_process
GO:0072190ureter urothelium developmentIEAbiological_process
GO:0030858positive regulation of epithelial cell differentiaIEAbiological_process
GO:0030903notochord developmentIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0060041retina development in camera-type eyeIEAbiological_process
GO:0060784regulation of cell proliferation involved in tissuIEAbiological_process
GO:0001934positive regulation of protein phosphorylationIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0051216cartilage developmentIEAbiological_process
GO:0090090negative regulation of canonical Wnt receptor signISSbiological_process
GO:0001503ossificationIEAbiological_process
GO:0071364cellular response to epidermal growth factor stimuISSbiological_process
GO:0060174limb bud formationIEAbiological_process
GO:0019100male germ-line sex determinationIEAbiological_process
GO:0035019somatic stem cell maintenanceIEAbiological_process
GO:2000741positive regulation of mesenchymal stem cell diffeIDAbiological_process
GO:0001502cartilage condensationISSbiological_process
GO:0005634nucleusIDAcellular_component
GO:0001046core promoter sequence-specific DNA bindingIDAmolecular_function
GO:0001501skeletal system developmentIMPbiological_process
GO:0030879mammary gland developmentIEAbiological_process
GO:0050680negative regulation of epithelial cell proliferatiISSbiological_process
GO:0046533negative regulation of photoreceptor cell differenISSbiological_process
GO:0007283spermatogenesisIEAbiological_process
GO:0032331negative regulation of chondrocyte differentiationIEAbiological_process
GO:0071504cellular response to heparinIEAbiological_process
GO:0071599otic vesicle developmentIEAbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaISSbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0016585chromatin remodeling complexIDAcellular_component
GO:0070168negative regulation of biomineral tissue developmeISSbiological_process
GO:0030155regulation of cell adhesionIEAbiological_process
GO:0061036positive regulation of cartilage developmentIEAbiological_process
GO:0071560cellular response to transforming growth factor beIDAbiological_process
GO:0030279negative regulation of ossificationIEAbiological_process
GO:0060041retina development in camera-type eyeISSbiological_process
GO:0072289metanephric nephron tubule formationIEAbiological_process
GO:0032332positive regulation of chondrocyte differentiationIMPbiological_process
GO:0007165signal transductionIEAbiological_process
GO:2000138positive regulation of cell proliferation involvedIEAbiological_process
GO:0014032neural crest cell developmentIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIMPbiological_process
GO:0061138morphogenesis of a branching epitheliumISSbiological_process
GO:0001934positive regulation of protein phosphorylationISSbiological_process
GO:0071347cellular response to interleukin-1IEPbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0001502cartilage condensationIEAbiological_process
GO:0030198extracellular matrix organizationIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0045732positive regulation of protein catabolic processIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIEAmolecular_function
GO:0070371ERK1 and ERK2 cascadeIEAbiological_process
GO:0005667transcription factor complexIEAcellular_component
GO:0008584male gonad developmentIEAbiological_process
GO:0003170heart valve developmentIEAbiological_process
GO:0071560cellular response to transforming growth factor beIEAbiological_process
GO:0060517epithelial cell proliferation involved in prostatiISSbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiIEAmolecular_function
GO:0006334nucleosome assemblyIDAbiological_process
GO:0072170metanephric tubule developmentIEAbiological_process
GO:0002683negative regulation of immune system processISSbiological_process
GO:0051216cartilage developmentISSbiological_process
GO:0071300cellular response to retinoic acidIEAbiological_process
GO:0019933cAMP-mediated signalingIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0090103cochlea morphogenesisIEAbiological_process
GO:0001708cell fate specificationIEAbiological_process
GO:0010564regulation of cell cycle processIMPbiological_process
GO:0008013beta-catenin bindingIEAmolecular_function
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiIDAmolecular_function
GO:0043425bHLH transcription factor bindingIEAmolecular_function
GO:0072034renal vesicle inductionISSbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0070371ERK1 and ERK2 cascadeISSbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0045595regulation of cell differentiationIEAbiological_process
GO:0035019somatic stem cell maintenanceISSbiological_process
GO:0002063chondrocyte developmentIEAbiological_process
GO:0070168negative regulation of biomineral tissue developmeIEAbiological_process
GO:0002053positive regulation of mesenchymal cell proliferatIEAbiological_process
GO:0001077RNA polymerase II core promoter proximal region seIDAmolecular_function
GO:0048709oligodendrocyte differentiationIEAbiological_process
GO:0060221retinal rod cell differentiationIEAbiological_process
GO:0060350endochondral bone morphogenesisIEAbiological_process
GO:0032332positive regulation of chondrocyte differentiationIEAbiological_process
GO:0030850prostate gland developmentIEPbiological_process
GO:0035326enhancer bindingIEAmolecular_function
GO:0001658branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0090190positive regulation of branching involved in ureteIEAbiological_process
GO:0030238male sex determinationIEAbiological_process
GO:0001158enhancer sequence-specific DNA bindingISSmolecular_function