| UniProt/SwissProt ID: | CCR4_HUMAN |
| Description: | chemokine (C-C motif) receptor 4 [Source:HGNC Symbol;Acc:1605] |
| Location: | chr3 p22.3 |
| Node attribute: | GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y191 | YCKTKySLNST | 7tm_1 | PhosphoSitePlus |
| Dephosphorylation site |
| CCR4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000332659 | S91F | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000332659 | L151F | COSMIC | Lung Cancer | 20668451 | ENSP00000332659 | F254I | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| CCR4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CCR4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CCR4_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| CCR4_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| CCR4_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| CCR4_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04062 | Chemokine signaling pathway |
| hsa05203 | Viral carcinogenesis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006955 | immune response | TAS | biological_process |
| GO:0001764 | neuron migration | IEA | biological_process |
| GO:0006935 | chemotaxis | IEA | biological_process |
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0006954 | inflammatory response | IEA | biological_process |
| GO:0007204 | elevation of cytosolic calcium ion concentration | TAS | biological_process |
| GO:0070098 | chemokine-mediated signaling pathway | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0016493 | C-C chemokine receptor activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0004950 | chemokine receptor activity | TAS | molecular_function |
| GO:0002507 | tolerance induction | IEA | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |