Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CAV1_HUMAN
Description:caveolin 1, caveolae protein, 22kDa [Source:HGNC Symbol;Acc:1527]
Location:chr7 q31.2
Node attribute:PPI(source); substrate; effector; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S88GIWKAsFTTFTCSNK2A2HPRD
S80PEGTHsFDGIWCaveolinPhosphoSitePlus
S88GIWKAsFTTFTCK2a1-rsRegPhos
S80PEGTHsFDGIWHPRD; phosphoELM; RegPhos
S88GIWKAsFTTFTCK2a2RegPhos
S88GIWKAsFTTFTCK2a1RegPhos
Y42SEKQVyDAHTKHPRD
Y6DSEGHPRD; phosphoELM; SysPTM
Y14SEGHLyTVPIRFynphosphoELM; RegPhos; SysPTM
Y42SEKQVyDAHTKCaveolinPhosphoSitePlus
Y25EQGNIyKPNNKHPRD; phosphoELM; RegPhos; SysPTM
Y6MSGGKyVDSEGPhosphoSitePlus; RegPhos; SysPTM
S88GIWKAsFTTFTCK2_groupphosphoELM; RegPhos
Y14SEGHLyTVPIRPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
Y14SEGHLyTVPIRSrcRegPhos; SysPTM
Y14SEGHLyTVPIRSRCHPRD; phosphoELM; RegPhos; SysPTM
S37MADELsEKQVYHPRD; phosphoELM; RegPhos; SysPTM
T46VYDAHtKEIDLCaveolinPhosphoSitePlus
S88GIWKAsFTTFTCSNK2A1HPRD
S9GKYVDsEGHLYPhosphoSitePlus
Y25EQGNIyKPNNKCaveolinPhosphoSitePlus; SysPTM
S168VGKIFsNVRINHPRD; phosphoELM; RegPhos
S37MADELsEKQVYCaveolinPhosphoSitePlus; SysPTM
T15EGHLYtVPIREPhosphoSitePlus

Dephosphorylation site
CAV1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000339191P132LHPIBreast Cancer12368209 22310961 21909981 20581046 20581045 19342880 19395651 17556531 16931572 16723714 15692148 15355971 15539932 12631721 11289096

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000339191hepatitis C virusNormal vs. CancertissueUp4.218715028
ENSP00000339191Breast CancerNormal vs. CancertissueDown20560667
ENSP00000339191Breast CancerNormal vs. CancertissueDown0.4420739354
ENSP00000339191Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
CAV1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNAQ_HUMANCAV1_HUMANGprotein -> effectorgpDB
SRC_HUMANCAV1_HUMANkinase -> substrateHPRD; RegPhos
CSK22_HUMANCAV1_HUMANkinase -> substrateHPRD
CSK21_HUMANCAV1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANCAV1_HUMANkinase -> substrateRegPhos
FYN_HUMANCAV1_HUMANkinase -> substrateRobert H Newman (2013)
CAV1_HUMANFYN_HUMANotherKEGG
TFDP1_HUMANCAV1_HUMANTF -> target geneTRANSFAC
SP1_HUMANCAV1_HUMANTF -> target geneTRANSFAC
P53_HUMANCAV1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05416Viral myocarditis
hsa05100Bacterial invasion of epithelial cells
hsa04144Endocytosis
hsa04510Focal adhesion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000139Golgi membraneIEAcellular_component
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0050998nitric-oxide synthase bindingIPImolecular_function
GO:0016504peptidase activator activityIEAmolecular_function
GO:0019915lipid storageIEAbiological_process
GO:0055074calcium ion homeostasisISSbiological_process
GO:0060056mammary gland involutionIEAbiological_process
GO:0070836caveola assemblyIEAbiological_process
GO:0090090negative regulation of canonical Wnt receptor signIEAbiological_process
GO:0009968negative regulation of signal transductionIEAbiological_process
GO:0033138positive regulation of peptidyl-serine phosphorylaIDAbiological_process
GO:0008104protein localizationIEAbiological_process
GO:0010952positive regulation of peptidase activityIEAbiological_process
GO:0005938cell cortexIEAcellular_component
GO:0016323basolateral plasma membraneIDAcellular_component
GO:0001525angiogenesisIEAbiological_process
GO:0031397negative regulation of protein ubiquitinationIEAbiological_process
GO:0032091negative regulation of protein bindingIDAbiological_process
GO:0033484nitric oxide homeostasisIEAbiological_process
GO:0005113patched bindingIPImolecular_function
GO:0030879mammary gland developmentIEAbiological_process
GO:0097190apoptotic signaling pathwayIMPbiological_process
GO:0005887integral to plasma membraneIEAcellular_component
GO:0002026regulation of the force of heart contractionIEAbiological_process
GO:0033137negative regulation of peptidyl-serine phosphorylaIDAbiological_process
GO:0043409negative regulation of MAPK cascadeISSbiological_process
GO:0016020membraneIEAcellular_component
GO:0043409negative regulation of MAPK cascadeIEAbiological_process
GO:0046209nitric oxide metabolic processTASbiological_process
GO:0043234protein complexIEAcellular_component
GO:0030857negative regulation of epithelial cell differentiaIEAbiological_process
GO:0005768endosomeIDAcellular_component
GO:0019048virus-host interactionIEAbiological_process
GO:0051259protein oligomerizationIEAbiological_process
GO:0045019negative regulation of nitric oxide biosynthetic pIEAbiological_process
GO:0006874cellular calcium ion homeostasisIEAbiological_process
GO:0051592response to calcium ionIEAbiological_process
GO:0019217regulation of fatty acid metabolic processIEAbiological_process
GO:0032570response to progesterone stimulusIDAbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0002080acrosomal membraneIEAcellular_component
GO:0030879mammary gland developmentISSbiological_process
GO:0071455cellular response to hyperoxiaIMPbiological_process
GO:2001238positive regulation of extrinsic apoptotic signaliIMPbiological_process
GO:0043407negative regulation of MAP kinase activityIEAbiological_process
GO:0007519skeletal muscle tissue developmentIEAbiological_process
GO:0043627response to estrogen stimulusIEAbiological_process
GO:0046426negative regulation of JAK-STAT cascadeISSbiological_process
GO:0009267cellular response to starvationIEPbiological_process
GO:0051001negative regulation of nitric-oxide synthase activIEAbiological_process
GO:0051480cytosolic calcium ion homeostasisIDAbiological_process
GO:0032947protein complex scaffoldTASmolecular_function
GO:0042310vasoconstrictionIEAbiological_process
GO:0042632cholesterol homeostasisIEAbiological_process
GO:0001960negative regulation of cytokine-mediated signalingIEAbiological_process
GO:0005901caveolaIEAcellular_component
GO:0006641triglyceride metabolic processIEAbiological_process
GO:0048554positive regulation of metalloenzyme activityIEAbiological_process
GO:0052547regulation of peptidase activityIEAbiological_process
GO:0051899membrane depolarizationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0002931response to ischemiaIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0031410cytoplasmic vesicleIDAcellular_component
GO:0001666response to hypoxiaIEAbiological_process
GO:0045121membrane raftIDAcellular_component
GO:0005198structural molecule activityIDAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0046426negative regulation of JAK-STAT cascadeIEAbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0051260protein homooligomerizationIEAbiological_process
GO:0000188inactivation of MAPK activityIEAbiological_process
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0006940regulation of smooth muscle contractionIEAbiological_process
GO:0016324apical plasma membraneIDAcellular_component
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0030514negative regulation of BMP signaling pathwayIDAbiological_process
GO:0052547regulation of peptidase activityISSbiological_process
GO:0005102receptor bindingIPImolecular_function
GO:0005622intracellularIDAcellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0045907positive regulation of vasoconstrictionIEAbiological_process
GO:0030193regulation of blood coagulationIMPbiological_process
GO:0015485cholesterol bindingTASmolecular_function
GO:0042524negative regulation of tyrosine phosphorylation ofIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0050999regulation of nitric-oxide synthase activityTASbiological_process
GO:2001244positive regulation of intrinsic apoptotic signaliIMPbiological_process
GO:0001937negative regulation of endothelial cell proliferatIEAbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0090263positive regulation of canonical Wnt receptor signIMPbiological_process
GO:2000286receptor internalization involved in canonical WntIMPbiological_process
GO:0072584caveolin-mediated endocytosisIDAbiological_process
GO:0006816calcium ion transportIEAbiological_process
GO:0001570vasculogenesisIEAbiological_process
GO:0055074calcium ion homeostasisIEAbiological_process
GO:2000811negative regulation of anoikisIEAbiological_process
GO:0031295T cell costimulationIDAbiological_process
GO:0007595lactationIEAbiological_process
GO:0005794Golgi apparatusIEAcellular_component
GO:0016050vesicle organizationIDAbiological_process
GO:0000165MAPK cascadeIEAbiological_process
GO:0030666endocytic vesicle membraneTAScellular_component
GO:0030301cholesterol transportTASbiological_process
GO:0032507maintenance of protein location in cellISSbiological_process
GO:0003057regulation of the force of heart contraction by chIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0010524positive regulation of calcium ion transport into IEAbiological_process
GO:0005811lipid particleTAScellular_component