Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CALM_HUMAN
Description:calmodulin 2 (phosphorylase kinase, delta) [Source:HGNC Symbol;Acc:1445]
Location:chr2 p21
Node attribute:effector; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y100KDGNGyISAAEINSRHPRD; phosphoELM; RegPhos; SysPTM
Y100KDGNGyISAAEDUF2267; TerB; DUF1103; EPhosphoSitePlus; SysPTM
Y100KDGNGyISAAEphosphoELM; RegPhos; SysPTM
S82MKDTDsEEEIRDUF2267; LNS2; TerB; TenuPhosphoSitePlus
Y139DGQVNyEEFVQDUF1103; EF_hand_5PhosphoSitePlus
Y139DGQVNyEEFVQINSRHPRD
T118LGEKLtDEEVDDUF2267; DUF1103; EF_handPhosphoSitePlus
T80RKMKDtDSEEEDUF2267; LNS2; TerB; TenuPhosphoSitePlus
S102GNGYIsAAELRDUF2267; TerB; DUF1103; EPhosphoSitePlus
S102GNGYIsAAELRCK2_groupphosphoELM; RegPhos
Y99DKDGNgYISAAHPRD
T45LGQNPtEAELQCaMK4 RegPhos
S102GNGYIsAAELRHPRD
Y100KDGNGyISAAEInsRRegPhos; SysPTM
Y100KDGNGyISAAEEGFRHPRD; phosphoELM; RegPhos; SysPTM
T80RKMKDtDSEEECK2_groupphosphoELM; RegPhos

Dephosphorylation site
CALM_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000349467*150LCOSMICHead and Neck Cancer21798893
ENSP00000375785*150LCOSMICHead and Neck Cancer21798893
ENSP00000291295*150LCOSMICHead and Neck Cancer21798893
ENSP00000291295M145ITCGAOvarian Cancer21720365, 18772890
ENSP00000272298*150LCOSMICHead and Neck Cancer21798893
ENSP00000291295M145ICOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000375785Hepatocellular CarcinomaNormal vs. Cancercell lineUp7.319120023
ENSP00000375785Neoplasms by Histologic TypeCancer vs. Cancercell lineUp15750928
ENSP00000375785Gastric CancerCancer vs. Cancer (good vs. proo survival)tissueUp518830628
ENSP00000375785Breast CancerNormal vs. Cancercell lineUp2.920052998
ENSP00000375785Breast CancerNormal vs. Cancercell lineUp3.820052998
ENSP00000375785Breast CancerNormal vs. Cancercell lineDown0.3820052998
ENSP00000375785Breast CancerNormal vs. Cancercell lineDown0.4720052998
ENSP00000375785Breast CancerMetastasiscell lineDown0.120052998
ENSP00000375785Breast CancerMetastasiscell lineDown0.1620052998
ENSP00000375785Renal CancerNormal vs. CancertissueDown0.4219610612
ENSP00000375785Renal CancerNormal vs. CancertissueDown0.4619610612

Hyperphosphorylation site
CALM_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG13_HUMANCALM_HUMANGprotein -> effectorgpDB
GBB1_HUMANCALM_HUMANGprotein -> effectorgpDB
GBB3_HUMANCALM_HUMANGprotein -> effectorgpDB
GBG5_HUMANCALM_HUMANGprotein -> effectorgpDB
GBG8_HUMANCALM_HUMANGprotein -> effectorgpDB
GBG3_HUMANCALM_HUMANGprotein -> effectorgpDB
GBB2_HUMANCALM_HUMANGprotein -> effectorgpDB
GBG1_HUMANCALM_HUMANGprotein -> effectorgpDB
GBB5_HUMANCALM_HUMANGprotein -> effectorgpDB
GBG2_HUMANCALM_HUMANGprotein -> effectorgpDB
GBG11_HUMANCALM_HUMANGprotein -> effectorgpDB
GBG10_HUMANCALM_HUMANGprotein -> effectorgpDB
GBG12_HUMANCALM_HUMANGprotein -> effectorgpDB
ZAGL2_HUMANCALM_HUMANkinase -> substrateRegPhos
EGFR_HUMANCALM_HUMANkinase -> substrateHPRD; RegPhos
INSR_HUMANCALM_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04722Neurotrophin signaling pathway
hsa05010Alzheimer's disease
hsa04114Oocyte meiosis
hsa04070Phosphatidylinositol signaling system
hsa04070Phosphatidylinositol signaling system
hsa04728Dopaminergic synapse
hsa05214Glioma
hsa05034Alcoholism
hsa04720Long-term potentiation
hsa05133Pertussis
hsa04916Melanogenesis
hsa05010Alzheimer's disease
hsa04740Olfactory transduction
hsa04020Calcium signaling pathway
hsa04744Phototransduction
hsa04722Neurotrophin signaling pathway
hsa04728Dopaminergic synapse
hsa04912GnRH signaling pathway
hsa05010Alzheimer's disease
hsa04971Gastric acid secretion
hsa04912GnRH signaling pathway
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04910Insulin signaling pathway
hsa04020Calcium signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa04740Olfactory transduction
hsa04910Insulin signaling pathway
hsa05133Pertussis
hsa05152Tuberculosis
hsa04728Dopaminergic synapse
hsa04270Vascular smooth muscle contraction
hsa04744Phototransduction
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04720Long-term potentiation
hsa04916Melanogenesis
hsa04970Salivary secretion
hsa05034Alcoholism
hsa05031Amphetamine addiction
hsa04270Vascular smooth muscle contraction
hsa05034Alcoholism
hsa04970Salivary secretion
hsa05031Amphetamine addiction
hsa04971Gastric acid secretion
hsa05133Pertussis
hsa04970Salivary secretion
hsa04114Oocyte meiosis
hsa04020Calcium signaling pathway
hsa04971Gastric acid secretion
hsa05152Tuberculosis
hsa04910Insulin signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04114Oocyte meiosis
hsa04744Phototransduction
hsa05152Tuberculosis
hsa05214Glioma
hsa05214Glioma
hsa05031Amphetamine addiction
hsa04740Olfactory transduction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031432titin bindingIPImolecular_function
GO:0002576platelet degranulationTASbiological_process
GO:0030168platelet activationTASbiological_process
GO:0051592response to calcium ionIDAbiological_process
GO:0005876spindle microtubuleIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0016301kinase activityIEAmolecular_function
GO:0046209nitric oxide metabolic processTASbiological_process
GO:0031997N-terminal myristoylation domain bindingIPImolecular_function
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0005980glycogen catabolic processTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005576extracellular regionTAScellular_component
GO:0019904protein domain specific bindingIPImolecular_function
GO:0000922spindle poleIDAcellular_component
GO:0006006glucose metabolic processTASbiological_process
GO:0060316positive regulation of ryanodine-sensitive calciumISSbiological_process
GO:0007165signal transductionTASbiological_process
GO:0006936muscle contractionTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0005813centrosomeIDAcellular_component
GO:0032465regulation of cytokinesisIMPbiological_process
GO:0010880regulation of release of sequestered calcium ion iISSbiological_process
GO:0043548phosphatidylinositol 3-kinase bindingIEAmolecular_function
GO:0050999regulation of nitric-oxide synthase activityTASbiological_process
GO:0051412response to corticosterone stimulusIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0048306calcium-dependent protein bindingIEAmolecular_function
GO:0005737cytoplasmTAScellular_component
GO:0043274phospholipase bindingIPImolecular_function
GO:0031996thioesterase bindingIPImolecular_function
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0060315negative regulation of ryanodine-sensitive calciumISSbiological_process
GO:0001975response to amphetamineIEAbiological_process
GO:0044325ion channel bindingIPImolecular_function