| UniProt/SwissProt ID: | ARAP1_HUMAN |
| Description: | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 [Source:HGNC Symbol;Acc:16925] |
| Location: | chr11 q13.4 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T354 | WVRLDtDHLRY | HPRD | |
| Y231 | FDDSDyDEVPE | HPRD | |
| T109 | WVRLDtDHLRY | HPRD | |
| Y431 | RLSSAyLLGVP | HPRD | |
| Y186 | RLSSAyLLGVP | HPRD | |
| S229 | PEFDDsDYDEV | HPRD | |
| Y492 | PLEKHySVVLP | HPRD | |
| S1190 | NEMRRsVAAFT | HPRD | |
| S428 | ARARLsSAYLL | HPRD | |
| S1435 | NEMRRsVAAFT | HPRD | |
| Y737 | PLEKHySVVLP | HPRD | |
| Y730 | IPVIVyRCVDY | HPRD | |
| T173 | LVSLPtKEEES | HPRD | |
| Y975 | IPVIVyRCVDY | HPRD | |
| S183 | ARARLsSAYLL | HPRD | |
| Y735 | IPVIVyRCVDY | phosphoELM | |
| Dephosphorylation site |
| ARAP1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000377230 | E527K | COSMIC | Skin Cancer | 21984974 | ENSP00000377230 | S188F | COSMIC | Melanoma | 21499247 | ENSP00000377230 | A884fs*34 | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| ARAP1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ARAP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FAK2_HUMAN | ARAP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK4_HUMAN | ARAP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KSYK_HUMAN | ARAP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK08_HUMAN | ARAP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| ARAP1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0051270 | regulation of cellular component movement | IMP | biological_process |
| GO:0030037 | actin filament reorganization involved in cell cyc | TAS | biological_process |
| GO:0005100 | Rho GTPase activator activity | IDA | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0051056 | regulation of small GTPase mediated signal transdu | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding | IDA | molecular_function |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005096 | GTPase activator activity | IEA | molecular_function |
| GO:0008060 | ARF GTPase activator activity | IEA | molecular_function |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0032312 | regulation of ARF GTPase activity | IEA | biological_process |
| GO:0051497 | negative regulation of stress fiber assembly | IMP | biological_process |
| GO:0007264 | small GTPase mediated signal transduction | TAS | biological_process |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0032580 | Golgi cisterna membrane | IEA | cellular_component |
| GO:0051491 | positive regulation of filopodium assembly | IMP | biological_process |
| GO:0008360 | regulation of cell shape | IMP | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0008060 | ARF GTPase activator activity | IDA | molecular_function |
| GO:0043089 | positive regulation of Cdc42 GTPase activity | IDA | biological_process |