Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:APOB_HUMAN
Description:apolipoprotein B (including Ag(x) antigen) [Source:HGNC Symbol;Acc:603]
Location:chr2 p24.1
Node attribute:ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1709ALTELsLGSAYPhosphoSitePlus
S3185NKHRHsITNPLPhosphoSitePlus
T2707PLARItLPDFRPhosphoSitePlus; HPRD
Y1287DGRVKyTLNKNPhosphoSitePlus
T2515AKFREtLEDTRPhosphoSitePlus; HPRD
T1102QNKKItEVALMPhosphoSitePlus
Y129AAMSRyELKLAVitellogenin_NPhosphoSitePlus
S3778KLRTSsFALNLPhosphoSitePlus; HPRD
Y4510QLSDYyEKFIAPhosphoSitePlus; HPRD
S4000KGISTsAASPAPhosphoSitePlus
Y1157SSATAyGSTVSPhosphoSitePlus
Y4025SKWNFyYSPQSPhosphoSitePlus
S3643RIHSGsFQSQVPhosphoSitePlus
S767IKDLKsKEVPEPhosphoSitePlus
S3402TALSLsNKFVEPhosphoSitePlus
Y2834KFSSKyLRTEHPhosphoSitePlus
S1235LIVAMsSWLQKPhosphoSitePlus
S4507FSDQLsDYYEKHPRD
Y276SYKNKyGMVAQVitellogenin_NPhosphoSitePlus
Y1840EIKHIyAISSAPhosphoSitePlus
S312GLAFEsTKSTSVitellogenin_NPhosphoSitePlus
T2013ELTGRtLADLTPhosphoSitePlus
Y2480ATVAVyLESLQPhosphoSitePlus
S4030YYSPQsSPDKKPhosphoSitePlus
T285AQVTQtLKLEDVitellogenin_NPhosphoSitePlus
Y3680IILPVyDKSLWPhosphoSitePlus
T1288GRVKYtLNKNSPhosphoSitePlus
S1135QAEARsEILAHPhosphoSitePlus
Y1714SLGSAyQAMILPhosphoSitePlus; HPRD
Y4116NAEWVyQGAIRPhosphoSitePlus
T3776YKKLRtSSFALHPRD
S4048LRVREsDEETQPhosphoSitePlus; HPRD
T4041LTIFKtELRVRPhosphoSitePlus
T1190DTKKMtSNFPVPhosphoSitePlus
S2022LTLLDsPIKVPHPRD
S3400LATALsLSNKFPhosphoSitePlus
Y1169RVAWHyDEEKIPhosphoSitePlus
S520QSTKPsLMIQKHPRD
S928KFIIPsPKRPVPhosphoSitePlus; HPRD; SysPTM
S4409EEKIVsLIKNLPhosphoSitePlus
Y4026KWNFYySPQSSPhosphoSitePlus
T3397GLKLAtALSLSPhosphoSitePlus
S4027WNFYYsPQSSPPhosphoSitePlus
T1114HLSCDtKEERKPhosphoSitePlus
S1723ILGVDsKNIFNHPRD
T3472SMLYStAKGAVPhosphoSitePlus
T3626ALNANtKNQKIPhosphoSitePlus
T2018TLADLtLLDSPHPRD
S3646SGSFQsQVELSPhosphoSitePlus
S2859SNTVAsLHTEKPhosphoSitePlus
T2862VASLHtEKNTLPhosphoSitePlus
S3198LCEFIsQSIKSPhosphoSitePlus
Y52KHLRKyTYNYEVitellogenin_NPhosphoSitePlus
S296TPKINsRFFGEVitellogenin_NPhosphoSitePlus

Dephosphorylation site
APOB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000233242R2520XBIOMARTColorectal Cancer21930507, 21930502
ENSP00000233242E1674GCOSMICCentral Nervous System Neoplasms18772396
ENSP00000233242I2262VCOSMICHepatocellular Carcinoma21822264
ENSP00000233242R2520*COSMICIntestines Cancer16959974
ENSP00000233242D4049ECOSMICOvarian Cancer21720365
ENSP00000233242V1030GCOSMICOvarian Cancer21720365
ENSP00000233242D1722NCOSMICHead and Neck Cancer21984974
ENSP00000233242F592SCOSMICCentral Nervous System Neoplasms18772396
ENSP00000233242I2641LBIOMARTBreast Cancer21930507, 21930502
ENSP00000233242R344KCOSMICSkin Cancer21984974
ENSP00000233242R4446TCOSMICOvarian Cancer21720365
ENSP00000233242F2564CHPIColorectal Cancer16959974
ENSP00000233242Q2497HCOSMICMelanoma21499247
ENSP00000233242S1653YCOSMICOvarian Cancer21720365
ENSP00000233242F2957ICOSMICOvarian Cancer21720365
ENSP00000233242Q3088KCOSMICOvarian Cancer21720365
ENSP00000233242E1046VBIOMARTBreast Cancer21930507, 21930502
ENSP00000233242K3627NCOSMICOvarian Cancer21720365
ENSP00000233242D2616HCOSMICSkin Cancer21984974
ENSP00000233242V3290ICOSMICPancreatic Cancer
ENSP00000233242L1527HCOSMICOvarian Cancer21720365
ENSP00000233242T1419ACOSMICOvarian Cancer21720365
ENSP00000233242E1976*COSMICMelanoma20016485
ENSP00000233242E2169KCOSMICSkin Cancer21984974
ENSP00000233242N1080SCOSMICHead and Neck Cancer21798897
ENSP00000233242G1227SCOSMICOvarian Cancer21720365
ENSP00000233242R2513*COSMICMelanoma21499247
ENSP00000233242H2748RBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000233242G3019ECOSMICMelanoma21499247
ENSP00000233242F2564CSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000233242R3059CCOSMICMelanoma21499247
ENSP00000233242I4266MCOSMICOvarian Cancer21720365
ENSP00000233242K3772NBIOMARTBreast Cancer21930507, 21930502
ENSP00000233242E2802KCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000233242hepatitis C virusNormal vs. CancertissueDown0.418715028
ENSP00000233242Lung CancerNormal vs. CancertissueDown0.317705522
ENSP00000233242Lung CancerNormal vs. CancertissueUp2.917705522

Hyperphosphorylation site
APOB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
APOB_HUMANLDLR_HUMANligand -> receptorHPMR
Q15552_HUMANAPOB_HUMANTF -> target geneTRANSFAC
AP2A_HUMANAPOB_HUMANTF -> target geneTRANSFAC
SP1_HUMANAPOB_HUMANTF -> target geneTRANSFAC
COT2_HUMANAPOB_HUMANTF -> target geneTRANSFAC
NFIC_HUMANAPOB_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANAPOB_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANAPOB_HUMANTF -> target geneTRANSFAC
CEBPA_HUMANAPOB_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04977Vitamin digestion and absorption
hsa04975Fat digestion and absorption

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0033344cholesterol effluxIEAbiological_process
GO:0034374low-density lipoprotein particle remodelingIMPbiological_process
GO:0008289lipid bindingIEAmolecular_function
GO:0006629lipid metabolic processIEAbiological_process
GO:0045540regulation of cholesterol biosynthetic processIEAbiological_process
GO:0034363intermediate-density lipoprotein particleIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0042627chylomicronIDAcellular_component
GO:0017127cholesterol transporter activityIMPmolecular_function
GO:0006629lipid metabolic processTASbiological_process
GO:0010884positive regulation of lipid storageIDAbiological_process
GO:0031983vesicle lumenIEAcellular_component
GO:0071379cellular response to prostaglandin stimulusIEAbiological_process
GO:0034359mature chylomicronIDAcellular_component
GO:0042157lipoprotein metabolic processIEAbiological_process
GO:0042159lipoprotein catabolic processIEAbiological_process
GO:0071356cellular response to tumor necrosis factorIEAbiological_process
GO:0010033response to organic substanceIEAbiological_process
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0030317sperm motilityIEAbiological_process
GO:0009743response to carbohydrate stimulusIEAbiological_process
GO:0006898receptor-mediated endocytosisTASbiological_process
GO:0042632cholesterol homeostasisIEAbiological_process
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0034379very-low-density lipoprotein particle assemblyICbiological_process
GO:0048844artery morphogenesisIEAbiological_process
GO:0005543phospholipid bindingIDAmolecular_function
GO:0016042lipid catabolic processIEAbiological_process
GO:0019433triglyceride catabolic processIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0008201heparin bindingIDAmolecular_function
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0050750low-density lipoprotein particle receptor bindingIMPmolecular_function
GO:0034362low-density lipoprotein particleIDAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0010886positive regulation of cholesterol storageIDAbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0008203cholesterol metabolic processIMPbiological_process
GO:0010744positive regulation of macrophage derived foam celIDAbiological_process
GO:0030301cholesterol transportIEAbiological_process
GO:0006869lipid transportIEAbiological_process
GO:0005615extracellular spaceISScellular_component
GO:0031904endosome lumenTAScellular_component
GO:0007399nervous system developmentIEAbiological_process
GO:0010269response to selenium ionIEAbiological_process
GO:0034360chylomicron remnantTAScellular_component
GO:0042953lipoprotein transportIEAbiological_process
GO:0034383low-density lipoprotein particle clearanceIMPbiological_process
GO:0007283spermatogenesisIEAbiological_process
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0009791post-embryonic developmentIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0034361very-low-density lipoprotein particleIEAcellular_component
GO:0010008endosome membraneTAScellular_component
GO:0005788endoplasmic reticulum lumenTAScellular_component
GO:0005488bindingIEAmolecular_function
GO:0042632cholesterol homeostasisIMPbiological_process
GO:0042158lipoprotein biosynthetic processIEAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0030301cholesterol transportIMPbiological_process
GO:0009566fertilizationIEAbiological_process
GO:0042157lipoprotein metabolic processTASbiological_process
GO:0006642triglyceride mobilizationIEAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0034361very-low-density lipoprotein particleIDAcellular_component
GO:0050900leukocyte migrationTASbiological_process
GO:0043231intracellular membrane-bounded organelleTAScellular_component
GO:0030669clathrin-coated endocytic vesicle membraneTAScellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0005319lipid transporter activityIEAmolecular_function
GO:0009615response to virusIEPbiological_process
GO:0012506vesicle membraneIEAcellular_component