Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ACTG_HUMAN
Description:actin, gamma 1 [Source:HGNC Symbol;Acc:144]
Location:chr17 q25.3
Node attribute:PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S368DESGPsIVHRKActinPhosphoSitePlus
T249DGQVItIGNERActinPhosphoSitePlus
S300ANTVLsGGTTMActinPhosphoSitePlus
T324ALAPStMKIKIActinPhosphoSitePlus
Y218KEKLCyVALDFHPRD
Y53GQKDSyVGDEAActinPhosphoSitePlus
T89KIWHHtFYNELActinPhosphoSitePlus
S323TALAPsTMKIKHPRD
S323TALAPsTMKIKActinPhosphoSitePlus
T201RGYSFtTTAERHPRD
Y294IRKDLyANTVLActinPhosphoSitePlus
Y362ISKQEyDESGPActinPhosphoSitePlus
T303VLSGGtTMYPGActinPhosphoSitePlus
S239SSLEKsYELPDActinPhosphoSitePlus
Y166HTVPIyEGYALActinPhosphoSitePlus
S52MGQKDsYVGDEActinPhosphoSitePlus
S155GIVMDsGDGVTActinPhosphoSitePlus
Y143AVLSLyASGRTActinPhosphoSitePlus
T297DLYANtVLSGGHPRD
S265ALFQPsFLGMEActinPhosphoSitePlus
Y294IRKDLyANTVLphosphoELM
S239SSLEKsYELPDHPRD
T318MQKEItALAPSActinPhosphoSitePlus
Y188RDLTDyLMKILActinPhosphoSitePlus
S33RAVFPsIVGRPActinPhosphoSitePlus
Y240SLEKSyELPDGActinPhosphoSitePlus
T186AGRDLtDYLMKActinPhosphoSitePlus
T203YSFTTtAEREIActinPhosphoSitePlus
S348GSILAsLSTFQActinPhosphoSitePlus
S60GDEAQsKRGILActinPhosphoSitePlus
T120NREKMtQIMFEActinPhosphoSitePlus
T194LMKILtERGYSActinPhosphoSitePlus
S365QEYDEsGPSIVActinPhosphoSitePlus
Y198LTERGySFTTTphosphoELM
Y218KEKLCyVALDFActinPhosphoSitePlus
T304LSGGTtMYPGIActinPhosphoSitePlus
Y69ILTLKyPIEHGActinPhosphoSitePlus
T202GYSFTtTAEREActinPhosphoSitePlus
Y306GGTTMyPGIADActinPhosphoSitePlus
S271FLGMEsCGIHEActinPhosphoSitePlus
S233ATAASsSSLEKHPRD
Y198LTERGySFTTTActinPhosphoSitePlus
T201RGYSFtTTAERActinPhosphoSitePlus
S199TERGYsFTTTAActinPhosphoSitePlus
Y169PIYEGyALPHAActinPhosphoSitePlus
Y91WHHTFyNELRVActinPhosphoSitePlus

Dephosphorylation site
ACTG_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000331514S233TCOSMICOvarian Cancer21720365
ENSP00000331514L180VCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000331514Prostate CancerTreatment (none vs. bicalutamide treatment)cell lineUp1.717152098
ENSP00000331514LeukemiaNormal vs. Cancercell lineUp2.817022645
ENSP00000331514LeukemiaNormal vs. Cancercell lineUp5.217022645
ENSP00000331514breast ductal carcinomaNormal vs. CancertissueUp18482919
ENSP00000331514breast ductal carcinomaNormal vs. CancertissueUp18564057
ENSP00000331514Pancreatic CancerNormal vs. CancertissueUp2.616230073
ENSP00000331514Pancreatic CancerNormal vs. CancertissueUp67019357035

Hyperphosphorylation site
ACTG_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDC42_HUMANACTG_HUMANotherKEGG
PAXI_HUMANACTG_HUMANotherKEGG
PI51C_HUMANACTG_HUMANotherKEGG
KPCA_HUMANACTG_HUMANotherKEGG
RAC1_HUMANACTG_HUMANotherKEGG
DIAP1_HUMANACTG_HUMANotherKEGG
ML12B_HUMANACTG_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05412Arrhythmogenic right ventricular cardiomyopathy (A
hsa05416Viral myocarditis
hsa05100Bacterial invasion of epithelial cells
hsa05164Influenza A
hsa04520Adherens junction
hsa04530Tight junction
hsa04510Focal adhesion
hsa05130Pathogenic Escherichia coli infection
hsa04810Regulation of actin cytoskeleton
hsa05414Dilated cardiomyopathy
hsa04670Leukocyte transendothelial migration
hsa05132Salmonella infection
hsa04145Phagosome
hsa05131Shigellosis
hsa05110Vibrio cholerae infection
hsa05410Hypertrophic cardiomyopathy (HCM)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0015629actin cytoskeletonIEAcellular_component
GO:0034332adherens junction organizationTASbiological_process
GO:0070062extracellular vesicular exosomeIDAcellular_component
GO:0007411axon guidanceTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0045214sarcomere organizationIEAbiological_process
GO:0045216cell-cell junction organizationTASbiological_process
GO:0005856cytoskeletonTAScellular_component
GO:0007596blood coagulationTASbiological_process
GO:0034329cell junction assemblyTASbiological_process
GO:0005200structural constituent of cytoskeletonIEAmolecular_function
GO:0030016myofibrilIEAcellular_component
GO:0031941filamentous actinIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0042802identical protein bindingIPImolecular_function
GO:0006928cellular component movementTASbiological_process
GO:0005829cytosolTAScellular_component


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