Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ACACA_HUMAN
Description:acetyl-CoA carboxylase alpha [Source:HGNC Symbol;Acc:84]
Location:chr17 q12
Node attribute:substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1179VMGCFsDSPPQHPRD
S66VSEDNsEDEISCSNK2A1HPRD
S66VSEDNsEDEISCSNK2A2HPRD
S66DLGISsLQDGLRegPhos
S1438VTKEAsFEYLQACC_centralPhosphoSitePlus
S87KEGSLsPASVGHPRD
S78LHIRSsMSGLHPKA_alphaphosphoELM
S23RFIIGsVSEDNPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y1499SMVMRyGSRLWACC_centralPhosphoSitePlus
S2380LSTMDsPHPRD
S29VSEDNsEDEISCSNK2A2HPRD
S29VSEDNsEDEISCSNK2A1HPRD
S2021VVIDSsINPRHHPRD
Y1370EEDRIyRHLEPACC_centralPhosphoSitePlus
S1181GCFSDsPPQSPHPRD
S1201TLNRMsFSSNLPRKAA1HPRD
Y1363EASFEyLQNEGHPRD
S1185DSPPQsPTFPEHPRD
T1187PPQSPtFPEAGHPRD
S29VSEDNsEDEISCK2a1RegPhos
S1138MTHVAsVSDVLHPRD
S1238TLNRMsFSSNLHPRD
S1201TLNRMsFSSNLAMPK_groupphosphoELM; RegPhos
S1257VMGCFsDSPPQHPRD
S2285LSTMDsPHPRD
Y867NVMNGyCLPDPACC_centralPhosphoSitePlus
Y676DVELIyEGVKYPhosphoSitePlus
S2041VVIDSsINPRHHPRD
S80IRSSMsGLHLVAMPKa1RegPhos
S80IRSSMsGLHLVAMPKa2RegPhos
S115LHIRSsMSGLHHPRD
Y2145RHMEMyADRESHPRD
S1380VTKEAsFEYLQHPRD
S1158MTHVAsVSDVLHPRD
S22QRSSMsGLHLVPRKAA2HPRD
Y1383EASFEyLQNEGHPRD
S2265LSTMDsPHPRD
Y2108RHMEMyADRESHPRD; RegPhos
S117IRSSMsGLHLVHPRD
S90SLSPAsVGSDTHPRD
S1218HVASVsDVLLDACC_centralPhosphoSitePlus
S1201TLNRMsFSSNLPKA_alphaphosphoELM
S117IRSSMsGLHLVPRKAA2HPRD
S117IRSSMsGLHLVPRKAA1HPRD
S85EEKEGsLSPASHPRD
T1265PPQSPtFPEAGHPRD; phosphoELM
S56PASVGsDTLSDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1296GCFSDsPPQSPHPRD
S42IMDEPsPLAQPHPRD
S22QRSSMsGLHLVPRKAA1HPRD
S48EEKEGsLSPASPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1201GCFSDsPPQSPHPRD
S1259GCFSDsPPQSPHPRD; phosphoELM
S2343LSTMDsPHPRD
S93PASVGsDTLSDHPRD
Y434QDGSFyFLELNCPSase_L_D2PhosphoSitePlus
S29VSEDNsEDEISCK2a2RegPhos
Y2144RVDPVyIHLAECarboxyl_transPhosphoSitePlus
S1205DSPPQsPTFPEHPRD
T964KNLLVtMLIDQHPRD
S60GSDTLsDLGISPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S25IIGSVsEDNSECaM-KI_groupphosphoELM
T1302PPQSPtFPEAGHPRD
S1238TLNRMsFSSNLPRKAA1HPRD
S1201TLNRMsFSSNLAMPKa1RegPhos
S5LAQPHPRD
S2099VVIDSsINPRHCarboxyl_transPhosphoSitePlus
S1199VMGCFsDSPPQHPRD
Y1441EASFEyLQNEGACC_centralPhosphoSitePlus
S2343LSTMDsPST__PhosphoSitePlus
S1201TLNRMsFSSNLPKA alphaRegPhos
T1042KNLLVtMLIDQACC_centralPhosphoSitePlus
S1216MTHVAsVSDVLHPRD; RegPhos
S1475VTKEAsFEYLQHPRD
S2136VVIDSsINPRHHPRD
S66DLGISsLQDGLCK2a1RegPhos
T95SVGSDtLSDLGHPRD
S1300DSPPQsPTFPEHPRD
T1042KNLLVtMLIDQHPRD; RegPhos
Y2050RHMEMyADRESHPRD
S1216MTHVAsVSDVLACC_centralPhosphoSitePlus
S66DLGISsLQDGLCK2a2RegPhos
S78LHIRSsMSGLHPKA alphaRegPhos
S1123TLNRMsFSSNLHPRD
S1263DSPPQsPTFPEHPRD; phosphoELM; RegPhos
T1207PPQSPtFPEAGHPRD
S1438VTKEAsFEYLQHPRD
S1294VMGCFsDSPPQHPRD
T1265PPQSPtFPEAGACC_centralPhosphoSitePlus
Y2030RHMEMyADRESHPRD
S66VSEDNsEDEISHPRD
S1844IQVENsHLILTCarboxyl_transPhosphoSitePlus
S5_MDEPsPLAQPPhosphoSitePlus
S1238MGGMVsFRTFERegPhos
Y2108RHMEMyADRESCarboxyl_transPhosphoSitePlus
Y1209SNLNHyGMTHVACC_centralPhosphoSitePlus
T1079KNLLVtMLIDQHPRD
S29VSEDNsEDEISPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S78LHIRSsMSGLHPhosphoSitePlus; HPRD; RegPhos
S80IRSSMsGLHLVAMPK_groupphosphoELM; RegPhos
S29VSEDNsEDEISCK2a1-rsRegPhos
Y855HRVFHyVLDNLACC_centralPhosphoSitePlus
S2099VVIDSsINPRHHPRD; RegPhos
S29VSEDNsEDEISCK2_groupphosphoELM; RegPhos
S22QRSSMsGLHLVHPRD
S1201TLNRMsFSSNLHPRD; phosphoELM; RegPhos
S66DLGISsLQDGLCK2a1-rsRegPhos
S97GSDTLsDLGISHPRD
Y290LYEKGyVKDVDCPSase_L_D2PhosphoSitePlus
S77ALHIRsSMSGLPhosphoSitePlus; phosphoELM; RegPhos
T1073QLSKTtNAKVAACC_centralPhosphoSitePlus
T1227LDNSFtPPCQRACC_centralPhosphoSitePlus
S80IRSSMsGLHLVPRKAA2HPRD
S80IRSSMsGLHLVPRKAA1HPRD
S25IIGSVsEDNSECaMK1_groupRegPhos
T58SVGSDtLSDLGHPRD; phosphoELM; RegPhos
T984KNLLVtMLIDQHPRD
S1259GCFSDsPPQSPACC_centralPhosphoSitePlus
T1849SHLILtGAGALCarboxyl_transPhosphoSitePlus
S25IIGSVsEDNSEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y286VPQELyEKGYVCPSase_L_D2PhosphoSitePlus
S1201TLNRMsFSSNLACC_centralPhosphoSitePlus
S1360VTKEAsFEYLQHPRD
S50KEGSLsPASVGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1263DSPPQsPTFPEACC_centralPhosphoSitePlus
Y801SGCIHyVKRPGBiotin_lipoylPhosphoSitePlus
Y417AKMVGyVSAGTCPSase_L_D2PhosphoSitePlus
S80IRSSMsGLHLVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1844IQVENsHLILTRegPhos
Y1478EASFEyLQNEGHPRD
S53SLSPAsVGSDTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1253MTHVAsVSDVLHPRD
S60RFIIGsVSEDNHPRD
S488SPWGDsPIDFEPhosphoSitePlus; phosphoELM
S1908PKSVHsSVPLLCarboxyl_transPhosphoSitePlus
S62IIGSVsEDNSEHPRD
S20MLQRSsMSGLHHPRD
S1238MGGMVsFRTFEAMPKa1RegPhos
S1143TLNRMsFSSNLHPRD
Y1441EASFEyLQNEGHPRD
Y1342RKQVNyEVDRRACC_centralPhosphoSitePlus
T1196RGNIPtLNRMSACC_centralPhosphoSitePlus
Y734EEVDRyRITIGPhosphoSitePlus

Dephosphorylation site
ACACA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000353898G2094VCOSMICHead and Neck Cancer21984974
ENSP00000377928R1687QHPIColorectal Cancer16959974
ENSP00000353898R1629QCOSMICIntestines Cancer16959974
ENSP00000377928R1687QSjoblom2006Intestines Cancer16959974

Differential expressed protein
ACACA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ACACA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AAPK2_HUMANACACA_HUMANkinase -> substrateRegPhos
CSK21_HUMANACACA_HUMANkinase -> substrateHPRD
KPCA_HUMANACACA_HUMANkinase -> substrateRobert H Newman (2013)
AAKG2_HUMANACACA_HUMANkinase -> substrateKEGG
ZAGL2_HUMANACACA_HUMANkinase -> substrateRegPhos
AAPK1_HUMANACACA_HUMANkinase -> substrateHPRD
CSK22_HUMANACACA_HUMANkinase -> substrateHPRD
SRBP1_HUMANACACA_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04910Insulin signaling pathway
hsa00061Fatty acid biosynthesis
hsa01100Metabolic pathways
hsa00620Pyruvate metabolism
hsa00640Propanoate metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051289protein homotetramerizationISSbiological_process
GO:0035338long-chain fatty-acyl-CoA biosynthetic processTASbiological_process
GO:2001295malonyl-CoA biosynthetic processIEAbiological_process
GO:0055088lipid homeostasisIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0051289protein homotetramerizationIEAbiological_process
GO:0008152metabolic processIEAbiological_process
GO:0003824catalytic activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0016874ligase activityIEAmolecular_function
GO:0006112energy reserve metabolic processTASbiological_process
GO:0005829cytosolISScellular_component
GO:0003989acetyl-CoA carboxylase activityIEAmolecular_function
GO:0009252peptidoglycan biosynthetic processIEAbiological_process
GO:0006633fatty acid biosynthetic processIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0001894tissue homeostasisIEAbiological_process
GO:0006084acetyl-CoA metabolic processISSbiological_process
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0006633fatty acid biosynthetic processISSbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0008716D-alanine-D-alanine ligase activityIEAmolecular_function
GO:0004075biotin carboxylase activityIEAmolecular_function
GO:0031325positive regulation of cellular metabolic processTASbiological_process
GO:0006084acetyl-CoA metabolic processIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0044268multicellular organismal protein metabolic processIEAbiological_process
GO:0019432triglyceride biosynthetic processTASbiological_process
GO:0006629lipid metabolic processIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0003989acetyl-CoA carboxylase activityISSmolecular_function


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