| UniProt/SwissProt ID: | ZIC4_HUMAN |
| Description: | Zic family member 4 [Source:HGNC Symbol;Acc:20393] |
| Location: | chr3 q24 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T227 | KIHKRtHTGEK | zf-C2H2 | PhosphoSitePlus |
| T229 | HKRTHtGEKPF | PhosphoSitePlus | |
| Dephosphorylation site |
| ZIC4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000372553 | V307M | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000372553 | V287M | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000372553 | F117L | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000372553 | C241W | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| ZIC4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ZIC4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CLK2_HUMAN | ZIC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DDR1_HUMAN | ZIC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AURKB_HUMAN | ZIC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| WEE1_HUMAN | ZIC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| VRK3_HUMAN | ZIC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | ZIC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| ZIC4_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005622 | intracellular | IEA | cellular_component |