| UniProt/SwissProt ID: | XPA_HUMAN |
| Description: | xeroderma pigmentosum, complementation group A [Source:HGNC Symbol;Acc:12814] |
| Location: | chr9 q22.33 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S196 | LEVWGsQEALE | DNAPK | RegPhos |
| S196 | LEVWGsQEALE | ATM | HPRD; RegPhos |
| S196 | LEVWGsQEALE | ATR | HPRD; RegPhos |
| S173 | KNPHHsQWGDM | DNAPK | RegPhos |
| S173 | KNPHHsQWGDM | XPA_C | PhosphoSitePlus |
| Y257 | LEDDMyRKTCT | DUF3797 | PhosphoSitePlus |
| S173 | KNPHHsQWGDM | PRKDC | HPRD |
| T239 | VWKREtIVHQH | PhosphoSitePlus | |
| Y48 | LAARPySATAA | PhosphoSitePlus | |
| S196 | LEVWGsQEALE | PRKDC | HPRD |
| S173 | KNPHHsQWGDM | ATR | HPRD; RegPhos |
| S173 | KNPHHsQWGDM | ATM | HPRD; RegPhos |
| S196 | LEVWGsQEALE | PhosphoSitePlus; phosphoELM; RegPhos | |
| Dephosphorylation site |
| XPA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000364270 | K221E | COSMIC | Breast Cancer | 20668451 |
| Differential expressed protein |
| XPA_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| XPA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PRKDC_HUMAN | XPA_HUMAN | kinase -> substrate | HPRD |
| ATR_HUMAN | XPA_HUMAN | kinase -> substrate | RegPhos |
| AKT1_HUMAN | XPA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK08_HUMAN | XPA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | XPA_HUMAN | kinase -> substrate | RegPhos |
| KS6A5_HUMAN | XPA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ATM_HUMAN | XPA_HUMAN | kinase -> substrate | RegPhos |
| CLK2_HUMAN | XPA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | XPA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK3_HUMAN | XPA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03420 | Nucleotide excision repair |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006289 | nucleotide-excision repair | IEA | biological_process |
| GO:0006979 | response to oxidative stress | IEA | biological_process |
| GO:0003684 | damaged DNA binding | IEA | molecular_function |
| GO:0042803 | protein homodimerization activity | IPI | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0019904 | protein domain specific binding | IPI | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0008630 | intrinsic apoptotic signaling pathway in response | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0009636 | response to toxin | IEA | biological_process |
| GO:0000718 | nucleotide-excision repair, DNA damage removal | TAS | biological_process |
| GO:0006289 | nucleotide-excision repair | TAS | biological_process |
| GO:0009411 | response to UV | IEA | biological_process |
| GO:0005634 | nucleus | TAS | cellular_component |
| GO:0000166 | nucleotide binding | IEA | molecular_function |