Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:UFO_HUMAN
Description:AXL receptor tyrosine kinase [Source:HGNC Symbol;Acc:905]
Location:chr19 q13.2
Node attribute:kinase; receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y821PDEILyVNMDEPhosphoSitePlus
S866PSTTPsPAQPAHPRD
Y772CLDGLyALMSRRegPhos
Y481KKETRyGEVFEPhosphoSitePlus; HPRD
Y779CLDGLyALMSRPkinase_TyrPhosphoSitePlus
Y634HSFLLySRLGDPkinase_TyrPhosphoSitePlus
S884PADRGsPAAPGPhosphoSitePlus; HPRD
Y770CLDGLyALMSRHPRD
S100DWIVVsQLRITV-setPhosphoSitePlus
Y821PDEILyVNMDEAXLHPRD
Y472KKETRyGEVFEHPRD
Y779CLDGLyALMSRAXLHPRD
S503YRVRKsYSRRTPhosphoSitePlus
Y859HPAGRyVLCPSAxlphosphoELM; RegPhos
T200PGLNKtSSFSCIg_2PhosphoSitePlus
S612GSEREsFPAPVPkinase_TyrPhosphoSitePlus
Y698LSKKIyNGDYYPkinase_TyrPhosphoSitePlus
Y702IYNGDyYRQGRHPRD
Y759ENSEIyDYLRQPkinase_TyrPhosphoSitePlus
Y814PDEILyVNMDEAXLRegPhos
Y702IYNGDyYRQGRPkinase_TyrPhosphoSitePlus
Y693IYNGDyYRQGRHPRD
S202LNKTSsFSCEAIg_2PhosphoSitePlus
Y859HPAGRyVLCPSRegPhos
S93DWIVVsQLRITRegPhos
Y726LADRVyTSKSDPkinase_TyrPhosphoSitePlus
Y703YNGDYyRQGRIPkinase_TyrPhosphoSitePlus
Y859HPAGRyVLCPSAXLRegPhos
S875PSTTPsPAQPAPhosphoSitePlus; HPRD
Y814PDEILyVNMDEAxlphosphoELM; RegPhos
S204KTSSFsCEAHNIg_2PhosphoSitePlus
Y772CLDGLyALMSRAxlphosphoELM; RegPhos
Y696YNGDYyRQGRIautocatalysis RegPhos
Y772CLDGLyALMSRAXLRegPhos
S875PADRGsPAAPGHPRD
Y814PDEILyVNMDERegPhos
Y857HPAGRyVLCPSHPRD
Y866HPAGRyVLCPSAXLHPRD
Y866HPAGRyVLCPSPhosphoSitePlus
S201GLNKTsSFSCEIg_2PhosphoSitePlus
Y643GDQPVyLPTQMPkinase_TyrPhosphoSitePlus
Y812PDEILyVNMDEHPRD

Dephosphorylation site
UFO_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000351995P304STCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000351995R295WGreenman2007Lung Cancer16140923, 17344846, 18428421
ENSP00000301178T343MBIOMARTBreast Cancer21930507, 21930502
ENSP00000351995T343MBIOMARTBreast Cancer21930507, 21930502
ENSP00000351995R492CGreenman2007Gastric Cancer17344846, 18428421
ENSP00000301178R499CHPIGastric Cancer17344846
ENSP00000301178L423QDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000301178R295WHPILung Cancer17344846

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000301178Testicular CancerNormal vs. Cancercell lineDown18489135
ENSP00000301178Pancreatic CancerNormal vs. CancertissueUp3.619199705

Hyperphosphorylation site
UFO_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GAS6_HUMANUFO_HUMANligand -> receptorHPMR
PROS_HUMANUFO_HUMANligand -> receptorHPMR
BMX_HUMANUFO_HUMANkinase -> substrateRobert H Newman (2013)
UFO_HUMANUFO_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANUFO_HUMANkinase -> substrateRegPhos
UFO_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
UFO_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001779natural killer cell differentiationIEAbiological_process
GO:0004714transmembrane receptor protein tyrosine kinase actIEAmolecular_function
GO:0030168platelet activationIEAbiological_process
GO:0045087innate immune responseIEAbiological_process
GO:0042698ovulation cycleIEAbiological_process
GO:0034101erythrocyte homeostasisIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0034446substrate adhesion-dependent cell spreadingIEAbiological_process
GO:0043491protein kinase B signaling cascadeIEAbiological_process
GO:0006909phagocytosisIDAbiological_process
GO:0051250negative regulation of lymphocyte activationIEAbiological_process
GO:0043277apoptotic cell clearanceIEAbiological_process
GO:0048469cell maturationIEPbiological_process
GO:0007165signal transductionTASbiological_process
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0060068vagina developmentIEAbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0097028dendritic cell differentiationIEPbiological_process
GO:0035457cellular response to interferon-alphaIDAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0001961positive regulation of cytokine-mediated signalingIDAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0007283spermatogenesisIEAbiological_process
GO:0021885forebrain cell migrationIEAbiological_process
GO:0032825positive regulation of natural killer cell differeIDAbiological_process
GO:0001974blood vessel remodelingIEAbiological_process
GO:2000669negative regulation of dendritic cell apoptotic prIDAbiological_process
GO:0001764neuron migrationIEAbiological_process
GO:0007167enzyme linked receptor protein signaling pathwayIEAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0005887integral to plasma membraneTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0071222cellular response to lipopolysaccharideIDAbiological_process
GO:0032940secretion by cellIEAbiological_process
GO:0031668cellular response to extracellular stimulusIEAbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0032720negative regulation of tumor necrosis factor produIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0001786phosphatidylserine bindingIDAmolecular_function
GO:0032689negative regulation of interferon-gamma productionIDAbiological_process
GO:0006909phagocytosisIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0051897positive regulation of protein kinase B signaling IEAbiological_process