Phosphorylation

Ensembl ID	Cancer name	Design	Sample	Change	Ratio	Pubmed
ENSP00000316176	Hepatocellular Carcinoma	Normal vs. Cancer	tissue	Up	4.3	15759316
ENSP00000316176	Esophageal Cancer	Normal vs. Cancer	tissue	Down	0.4	19142970
ENSP00000316176	Breast Cancer	Normal vs. Cancer	cell line	Down	0.44	20052998
ENSP00000316176	Breast Cancer	Normal vs. Cancer	cell line	Up	1.3	20052998
ENSP00000316176	Breast Cancer	Metastasis	cell line	Up	3	20052998
ENSP00000316176	Breast Cancer	Metastasis	cell line	Down	0.31	20198662
ENSP00000316176	Oral Cancer	Normal vs. Cancer	tissue	Down	0.31	19691830
ENSP00000316176	Pancreatic Cancer	Normal vs. Cancer	tissue	Up	18	19199705

Hyperphosphorylation site

UBE2N_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
M3K7_HUMAN	UBE2N_HUMAN	kinase -> substrate	Robert H Newman (2013)
MAPK5_HUMAN	UBE2N_HUMAN	kinase -> substrate	Robert H Newman (2013)

Function Annotation

KEGG Pathway

UBE2N_HUMAN is not in KEGG pathway.

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0045739	positive regulation of DNA repair	IMP	biological_process
GO:0034130	toll-like receptor 1 signaling pathway	TAS	biological_process
GO:0006508	proteolysis	TAS	biological_process
GO:0000724	double-strand break repair via homologous recombin	IMP	biological_process
GO:0002755	MyD88-dependent toll-like receptor signaling pathw	TAS	biological_process
GO:0051092	positive regulation of NF-kappaB transcription fac	IMP	biological_process
GO:0006464	cellular protein modification process	TAS	biological_process
GO:0035872	nucleotide-binding domain, leucine rich repeat con	TAS	biological_process
GO:0034134	toll-like receptor 2 signaling pathway	TAS	biological_process
GO:0005634	nucleus	IDA	cellular_component
GO:0008063	Toll signaling pathway	TAS	biological_process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB c	IMP	biological_process
GO:0033182	regulation of histone ubiquitination	IMP	biological_process
GO:0005829	cytosol	TAS	cellular_component
GO:0031372	UBC13-MMS2 complex	IDA	cellular_component
GO:0034142	toll-like receptor 4 signaling pathway	TAS	biological_process
GO:0070423	nucleotide-binding oligomerization domain containi	TAS	biological_process
GO:0043130	ubiquitin binding	IDA	molecular_function
GO:0006511	ubiquitin-dependent protein catabolic process	IEA	biological_process
GO:0016881	acid-amino acid ligase activity	IEA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0000151	ubiquitin ligase complex	IDA	cellular_component
GO:0000729	DNA double-strand break processing	IMP	biological_process
GO:0031058	positive regulation of histone modification	IMP	biological_process
GO:0045087	innate immune response	TAS	biological_process
GO:0004842	ubiquitin-protein ligase activity	IDA	molecular_function
GO:0016567	protein ubiquitination	TAS	biological_process
GO:0050852	T cell receptor signaling pathway	IMP	biological_process
GO:0006301	postreplication repair	IMP	biological_process
GO:0051443	positive regulation of ubiquitin-protein ligase ac	IMP	biological_process
GO:0016574	histone ubiquitination	IMP	biological_process
GO:0019221	cytokine-mediated signaling pathway	TAS	biological_process
GO:0002224	toll-like receptor signaling pathway	TAS	biological_process
GO:0005524	ATP binding	IEA	molecular_function
GO:0035370	UBC13-UEV1A complex	IDA	cellular_component
GO:0005737	cytoplasm	TAS	cellular_component
GO:0070534	protein K63-linked ubiquitination	IDA	biological_process
GO:0006282	regulation of DNA repair	TAS	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network