Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TPOR_HUMAN
Description:myeloproliferative leukemia virus oncogene [Source:HGNC Symbol;Acc:7217]
Location:chr1 p34.2
Node attribute:receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S81ACPLSsQSMPHEpoR_lig-bindPhosphoSitePlus
Y626IANHSyLPLSYHPRD; phosphoELM
Y631YLPLSyWQQP_PhosphoSitePlus
T546QYLRDtAALSPHPRD
Y591QAQMDyRRLQPPhosphoSitePlus
Y631YLPLSyWQHPRD; phosphoELM

Dephosphorylation site
TPOR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000361548Y591DCOSMICLymphoma18723266
ENSP00000361548L510PCOSMICLymphoma18528423
ENSP00000361548G540SCOSMICLymphoma21326037
ENSP00000361548R71WCOSMICHead and Neck Cancer21798897
ENSP00000361548W515LCOSMICLymphoma16868251
ENSP00000361548V501LCOSMICLymphoma21326037
ENSP00000361548S505NCOSMICLymphoma21326037
ENSP00000361548A519VCOSMICLymphoma21326037
ENSP00000361548A506TCOSMICLymphoma18528423
ENSP00000361548V507ICOSMICLymphoma21326037
ENSP00000361548S204FCOSMICLymphoma18723266
ENSP00000361548G509CCOSMICLymphoma20151976
ENSP00000361548T487ACOSMICLymphoma18755984
ENSP00000361548Q424*COSMICPancreatic Cancer
ENSP00000361548R514KCOSMICLymphoma21326037
ENSP00000361548D545NCOSMICLymphoma21326037

Differential expressed protein
TPOR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TPOR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TPO_HUMANTPOR_HUMANligand -> receptorHPMR
PERT_HUMANTPOR_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007596blood coagulationTASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0048872homeostasis of number of cellsIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0004888transmembrane signaling receptor activityTASmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0032642regulation of chemokine productionIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0004896cytokine receptor activityIEAmolecular_function
GO:0008283cell proliferationTASbiological_process
GO:0007166cell surface receptor signaling pathwayTASbiological_process


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