Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PERT_HUMAN
Description:thyroid peroxidase [Source:HGNC Symbol;Acc:12015]
Location:chr2 p25.3
Node attribute:PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S97EIMETsIQAMKPhosphoSitePlus
T891ETGGGtPELRCPhosphoSitePlus
T561MNEELtERLFVPhosphoSitePlus
T52KRLVDtAMYATPhosphoSitePlus
T57TAMYAtMQRNLPhosphoSitePlus

Dephosphorylation site
PERT_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000318820N557YCOSMICLung Cancer
ENSP00000318820R684CCOSMICOvarian Cancer20826764
ENSP00000329869H805LTCGAOvarian Cancer21720365, 18772890
ENSP00000329869S322LCOSMICMelanoma
ENSP00000318820C808fs*24COSMICPancreatic Cancer
ENSP00000329869D585ECOSMICOvarian Cancer21720365
ENSP00000318820E28KCOSMICMelanoma21499247
ENSP00000329869A576ETCGAOvarian Cancer21720365, 18772890
ENSP00000318820D585ECOSMICOvarian Cancer21720365
ENSP00000329869E28KCOSMICMelanoma21499247
ENSP00000318820D796fs*2COSMICRenal Cancer20054297
ENSP00000329869Q738ECOSMICHead and Neck Cancer21798893
ENSP00000329869R684CCOSMICOvarian Cancer20826764
ENSP00000329869D796fs*2COSMICRenal Cancer20054297
ENSP00000318820S322LCOSMICMelanoma
ENSP00000318820L11VCOSMICOvarian Cancer21720365
ENSP00000329869D834NTCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000329869A576ECOSMICOvarian Cancer21720365
ENSP00000329869P268ACOSMICPancreatic Cancer
ENSP00000329869H805LCOSMICOvarian Cancer21720365
ENSP00000318820P268ACOSMICPancreatic Cancer
ENSP00000318820H805LCOSMICOvarian Cancer21720365
ENSP00000329869I622NCOSMICPancreatic Cancer
ENSP00000318820I622NCOSMICPancreatic Cancer
ENSP00000329869D585ETCGAOvarian Cancer21720365, 18772890
ENSP00000329869L11VCOSMICOvarian Cancer21720365
ENSP00000318820H805LTCGAOvarian Cancer21720365, 18772890
ENSP00000329869C808fs*24COSMICPancreatic Cancer
ENSP00000329869N557YCOSMICLung Cancer
ENSP00000318820D834NTCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000318820A576ECOSMICOvarian Cancer21720365
ENSP00000318820Q738ECOSMICHead and Neck Cancer21798893
ENSP00000318820A576ETCGAOvarian Cancer21720365, 18772890
ENSP00000318820D585ETCGAOvarian Cancer21720365, 18772890

Differential expressed protein
PERT_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PERT_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PERT_HUMANTPOR_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa01100Metabolic pathways
hsa04630Jak-STAT signaling pathway
hsa04640Hematopoietic cell lineage
hsa00350Tyrosine metabolism
hsa04060Cytokine-cytokine receptor interaction
hsa05320Autoimmune thyroid disease

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042446hormone biosynthetic processIEAbiological_process
GO:0004447iodide peroxidase activityIEAmolecular_function
GO:0006590thyroid hormone generationIEAbiological_process
GO:0035162embryonic hemopoiesisIDAbiological_process
GO:0055114oxidation-reduction processIEAbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0005739mitochondrionIEAcellular_component
GO:0034641cellular nitrogen compound metabolic processTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0004601peroxidase activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005887integral to plasma membraneTAScellular_component
GO:0042744hydrogen peroxide catabolic processIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0006979response to oxidative stressIEAbiological_process
GO:0020037heme bindingIEAmolecular_function


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