Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TPO_HUMAN
Description:thrombopoietin [Source:HGNC Symbol;Acc:11795]
Location:chr3 q27.1
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T205SGLLEtNFTASPhosphoSitePlus
S68PAVDFsLGEWKEPO_TPOPhosphoSitePlus
S216ARTTGsGLLKWPhosphoSitePlus
T58VHPLPtPVLLPEPO_TPOPhosphoSitePlus
T79TQMEEtKAQDIEPO_TPOPhosphoSitePlus

Dephosphorylation site
TPO_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000204615L195PCOSMICOvarian Cancer21720365
ENSP00000204615E252KCOSMICSkin Cancer21984974
ENSP00000204615H44YBIOMARTBreast Cancer21930507, 21930502
ENSP00000410763H44YBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
TPO_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TPO_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TPO_HUMANTPOR_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04640Hematopoietic cell lineage

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005125cytokine activityIEAmolecular_function
GO:0008283cell proliferationIEAbiological_process
GO:0030099myeloid cell differentiationIEAbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0005615extracellular spaceIEAcellular_component
GO:0007275multicellular organismal developmentTASbiological_process
GO:0005179hormone activityIEAmolecular_function
GO:0008083growth factor activityTASmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0030168platelet activationTASbiological_process


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