| UniProt/SwissProt ID: | TPO_HUMAN |
| Description: | thrombopoietin [Source:HGNC Symbol;Acc:11795] |
| Location: | chr3 q27.1 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T205 | SGLLEtNFTAS | PhosphoSitePlus | |
| S68 | PAVDFsLGEWK | EPO_TPO | PhosphoSitePlus |
| S216 | ARTTGsGLLKW | PhosphoSitePlus | |
| T58 | VHPLPtPVLLP | EPO_TPO | PhosphoSitePlus |
| T79 | TQMEEtKAQDI | EPO_TPO | PhosphoSitePlus |
| Dephosphorylation site |
| TPO_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000204615 | L195P | COSMIC | Ovarian Cancer | 21720365 | ENSP00000204615 | E252K | COSMIC | Skin Cancer | 21984974 | ENSP00000204615 | H44Y | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000410763 | H44Y | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| TPO_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TPO_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TPO_HUMAN | TPOR_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04640 | Hematopoietic cell lineage |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005125 | cytokine activity | IEA | molecular_function |
| GO:0008283 | cell proliferation | IEA | biological_process |
| GO:0030099 | myeloid cell differentiation | IEA | biological_process |
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0007275 | multicellular organismal development | TAS | biological_process |
| GO:0005179 | hormone activity | IEA | molecular_function |
| GO:0008083 | growth factor activity | TAS | molecular_function |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0030168 | platelet activation | TAS | biological_process |