| UniProt/SwissProt ID: | TPOR_HUMAN |
| Description: | myeloproliferative leukemia virus oncogene [Source:HGNC Symbol;Acc:7217] |
| Location: | chr1 p34.2 |
| Node attribute: | receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S81 | ACPLSsQSMPH | EpoR_lig-bind | PhosphoSitePlus |
| Y626 | IANHSyLPLSY | HPRD; phosphoELM | |
| Y631 | YLPLSyWQQP_ | PhosphoSitePlus | |
| T546 | QYLRDtAALSP | HPRD | |
| Y591 | QAQMDyRRLQP | PhosphoSitePlus | |
| Y631 | YLPLSyWQ | HPRD; phosphoELM | |
| Dephosphorylation site |
| TPOR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000361548 | Y591D | COSMIC | Lymphoma | 18723266 | ENSP00000361548 | L510P | COSMIC | Lymphoma | 18528423 | ENSP00000361548 | G540S | COSMIC | Lymphoma | 21326037 | ENSP00000361548 | R71W | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000361548 | W515L | COSMIC | Lymphoma | 16868251 | ENSP00000361548 | V501L | COSMIC | Lymphoma | 21326037 | ENSP00000361548 | S505N | COSMIC | Lymphoma | 21326037 | ENSP00000361548 | A519V | COSMIC | Lymphoma | 21326037 | ENSP00000361548 | A506T | COSMIC | Lymphoma | 18528423 | ENSP00000361548 | V507I | COSMIC | Lymphoma | 21326037 | ENSP00000361548 | S204F | COSMIC | Lymphoma | 18723266 | ENSP00000361548 | G509C | COSMIC | Lymphoma | 20151976 | ENSP00000361548 | T487A | COSMIC | Lymphoma | 18755984 | ENSP00000361548 | Q424* | COSMIC | Pancreatic Cancer | ENSP00000361548 | R514K | COSMIC | Lymphoma | 21326037 | ENSP00000361548 | D545N | COSMIC | Lymphoma | 21326037 |
| Differential expressed protein |
| TPOR_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TPOR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TPO_HUMAN | TPOR_HUMAN | ligand -> receptor | HPMR |
| PERT_HUMAN | TPOR_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04630 | Jak-STAT signaling pathway |
| hsa04060 | Cytokine-cytokine receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0048872 | homeostasis of number of cells | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0004888 | transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0032642 | regulation of chemokine production | IEA | biological_process |
| GO:0030168 | platelet activation | TAS | biological_process |
| GO:0004896 | cytokine receptor activity | IEA | molecular_function |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0007166 | cell surface receptor signaling pathway | TAS | biological_process |