Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TNR6_HUMAN
Description:Fas (TNF receptor superfamily, member 6) [Source:HGNC Symbol;Acc:11920]
Location:chr10 q23.31
Node attribute:PPI(source); PPI(target); receptor; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S212QGSHEsPTLNPHPRD; phosphoELM
S212QGSHEsPTLNPPeptidase_M73PhosphoSitePlus
S188KENQGsHESPTHPRD
T193SHESPtLNPETHPRD
S322DITSDsENSNFPeptidase_M73PhosphoSitePlus
Y232VDLSKyITTIADeath; Peptidase_M73PhosphoSitePlus
T214SHESPtLNPETHPRD; phosphoELM
Y232VDLSKyITTIAphosphoELM
T219TLNPEtVAINLHPRD; phosphoELM
S209KENQGsHESPTPeptidase_M73PhosphoSitePlus
T241IAGVMtLSQVKDeath; Peptidase_M73PhosphoSitePlus
S209KENQGsHESPTHPRD; phosphoELM
Y91QEGKEyTDKAHphosphoELM
Y91QEGKEyTDKAHTNFR_c6PhosphoSitePlus
Y291GKKEAyDTLIKphosphoELM
T234LSKYItTIAGVDeath; Peptidase_M73PhosphoSitePlus
S191QGSHEsPTLNPHPRD
S243GVMTLsQVKGFDeath; Peptidase_M73PhosphoSitePlus
T219TLNPEtVAINLPeptidase_M73PhosphoSitePlus
S325SDSENsNFRNEPeptidase_M73PhosphoSitePlus
Y291GKKEAyDTLIKDeath; Peptidase_M73PhosphoSitePlus
T198TLNPEtVAINLHPRD

Dephosphorylation site
TNR6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000347979L180FHPILymphoma9787134
ENSP00000347979N255DHPINeoplasms by Histologic Type10620127
ENSP00000425159*150LCOSMICHead and Neck Cancer21798893
ENSP00000347979E211*COSMICHead and Neck Cancer21798893
ENSP00000347979L278FHPILymphoma9787134
ENSP00000347979D269NCOSMICHead and Neck Cancer
ENSP00000347979A25THPILymphoma9787134
ENSP00000347979P183LHPILymphoma9787134
ENSP00000347979C178RHPINeoplasms by Histologic Type10620127
ENSP00000347979N264KHPILymphoma9787134
ENSP00000422453*133KCOSMICMelanoma21499247
ENSP00000347979N118SHPINeoplasms by Histologic Type10620127
ENSP00000347979T198IHPILymphoma9787134
ENSP00000423755*150LCOSMICHead and Neck Cancer21798893
ENSP00000347979K299NHPILymphoma9787134

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000347979Uterine CancerTreatment(none vs. 5-Fluorouracil treatment)cell lineUp15585135

Hyperphosphorylation site
TNR6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TNFL6_HUMANTNR6_HUMANligand -> receptorHPMR
TNFL6_HUMANTNR6_HUMANotherKEGG
TNR6_HUMANDAXX_HUMANotherKEGG
TNR6_HUMANFADD_HUMANotherKEGG
P53_HUMANTNR6_HUMANTF -> target geneKEGG
SP1_HUMANTNR6_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05010Alzheimer's disease
hsa04060Cytokine-cytokine receptor interaction
hsa04210Apoptosis
hsa05162Measles
hsa05142Chagas disease (American trypanosomiasis)
hsa05143African trypanosomiasis
hsa05168Herpes simplex infection
hsa05332Graft-versus-host disease
hsa05330Allograft rejection
hsa04010MAPK signaling pathway
hsa05200Pathways in cancer
hsa04940Type I diabetes mellitus
hsa04115p53 signaling pathway
hsa05164Influenza A
hsa04650Natural killer cell mediated cytotoxicity
hsa05320Autoimmune thyroid disease

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005576extracellular regionIEAcellular_component
GO:0006919activation of cysteine-type endopeptidase activityTASbiological_process
GO:0045121membrane raftIDAcellular_component
GO:0031265CD95 death-inducing signaling complexIDAcellular_component
GO:0071285cellular response to lithium ionIEAbiological_process
GO:0006927transformed cell apoptotic processIEAbiological_process
GO:0042981regulation of apoptotic processNASbiological_process
GO:0051402neuron apoptotic processIEAbiological_process
GO:0019724B cell mediated immunityIEAbiological_process
GO:0019900kinase bindingIPImolecular_function
GO:0007165signal transductionTASbiological_process
GO:0031265CD95 death-inducing signaling complexIEAcellular_component
GO:0009636response to toxinIEAbiological_process
GO:0006917induction of apoptosisTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0032464positive regulation of protein homooligomerizationIEAbiological_process
GO:0045619regulation of lymphocyte differentiationIEAbiological_process
GO:0048536spleen developmentIEAbiological_process
GO:0006461protein complex assemblyTASbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0004871signal transducer activityTASmolecular_function
GO:0043029T cell homeostasisIEAbiological_process
GO:0002377immunoglobulin productionIEAbiological_process
GO:0050869negative regulation of B cell activationIEAbiological_process
GO:0006915apoptotic processIDAbiological_process
GO:0071455cellular response to hyperoxiaIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0004888transmembrane signaling receptor activityIEAmolecular_function
GO:0051384response to glucocorticoid stimulusIEAbiological_process
GO:0006924activation-induced cell death of T cellsIEAbiological_process
GO:0010940positive regulation of necrotic cell deathIMPbiological_process
GO:0045637regulation of myeloid cell differentiationIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0043065positive regulation of apoptotic processIMPbiological_process
GO:0008625extrinsic apoptotic signaling pathway via death doIEAbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0042802identical protein bindingIPImolecular_function
GO:0031264death-inducing signaling complexIDAcellular_component
GO:0006925inflammatory cell apoptotic processIEAbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0003014renal system processIEAbiological_process
GO:0005829cytosolNAScellular_component
GO:0010467gene expressionIEAbiological_process
GO:0004872receptor activityNASmolecular_function
GO:0045060negative thymic T cell selectionIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0051260protein homooligomerizationIEAbiological_process
GO:0071260cellular response to mechanical stimulusIEPbiological_process