Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:THRB_HUMAN
Description:coagulation factor II (thrombin) [Source:HGNC Symbol;Acc:3535]
Location:chr11 p11.2
Node attribute:ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y320TATSEyQTFFNThrombin_lightPhosphoSitePlus
T540VCKDStRIRITHPRD
S331PRTFGsGEADCThrombin_lightPhosphoSitePlus
S539PVCKDsTRIRITrypsinPhosphoSitePlus
S539PVCKDsTRIRIHPRD
T540VCKDStRIRITTrypsinPhosphoSitePlus
Y434HSRTRyERNIETrypsinPhosphoSitePlus

Dephosphorylation site
THRB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000308541Y67FCOSMICOvarian Cancer21720365
ENSP00000308541P471SCOSMICOvarian Cancer21720365
ENSP00000308541P471STCGAOvarian Cancer21720365, 18772890
ENSP00000308541Y67FTCGAOvarian Cancer21720365, 18772890
ENSP00000308541R198CTCGAOvarian Cancer21720365, 18772890
ENSP00000308541R198CCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000308541breast ductal carcinomaMetastasistissueDown19624269
ENSP00000308541Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineUp1.515169874
ENSP00000308541Ovarian CancerNormal vs. CancertissueUp2.320162585
ENSP00000308541Pancreatic CancerNormal vs. CancertissueUp<215526344

Hyperphosphorylation site
THRB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
THRB_HUMANPAR1_HUMANligand -> receptorHPMR
THRB_HUMANPAR4_HUMANligand -> receptorHPMR
THRB_HUMANPAR2_HUMANligand -> receptorHPMR
THRB_HUMANPAR3_HUMANligand -> receptorHPMR
FOXA2_HUMANTHRB_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANTHRB_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANTHRB_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction
hsa04610Complement and coagulation cascades
hsa04810Regulation of actin cytoskeleton

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051480cytosolic calcium ion homeostasisIDAbiological_process
GO:0004252serine-type endopeptidase activityIDAmolecular_function
GO:0051918negative regulation of fibrinolysisTASbiological_process
GO:0004252serine-type endopeptidase activityIEAmolecular_function
GO:0006953acute-phase responseIEAbiological_process
GO:0051281positive regulation of release of sequestered calcIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0001934positive regulation of protein phosphorylationIDAbiological_process
GO:0048712negative regulation of astrocyte differentiationIDAbiological_process
GO:1900738positive regulation of phospholipase C-activating IDAbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0030307positive regulation of cell growthIEAbiological_process
GO:0044267cellular protein metabolic processTASbiological_process
GO:0005102receptor bindingIPImolecular_function
GO:0032967positive regulation of collagen biosynthetic proceIDAbiological_process
GO:0043687post-translational protein modificationTASbiological_process
GO:0030193regulation of blood coagulationTASbiological_process
GO:0007275multicellular organismal developmentTASbiological_process
GO:2000379positive regulation of reactive oxygen species metIDAbiological_process
GO:0007597blood coagulation, intrinsic pathwayTASbiological_process
GO:0030168platelet activationIDAbiological_process
GO:0008360regulation of cell shapeIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0010544negative regulation of platelet activationTASbiological_process
GO:0005796Golgi lumenTAScellular_component
GO:0050900leukocyte migrationTASbiological_process
GO:0030168platelet activationIEAbiological_process
GO:0070053thrombospondin receptor activityIDAmolecular_function
GO:0005615extracellular spaceIDAcellular_component
GO:0005788endoplasmic reticulum lumenTAScellular_component
GO:0017187peptidyl-glutamic acid carboxylationTASbiological_process
GO:0003824catalytic activityIEAmolecular_function
GO:0006508proteolysisTASbiological_process
GO:0042730fibrinolysisIDAbiological_process
GO:0045861negative regulation of proteolysisIDAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0008083growth factor activityTASmolecular_function
GO:0030194positive regulation of blood coagulationIDAbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0007166cell surface receptor signaling pathwayIDAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0008233peptidase activityIEAmolecular_function
GO:0009611response to woundingIDAbiological_process


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