| UniProt/SwissProt ID: | TGFI1_HUMAN |
| Description: | transforming growth factor beta 1 induced transcript 1 [Source:HGNC Symbol;Acc:11767] |
| Location: | chr16 p11.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S186 | QPPVVsSTNEG | HPRD | |
| S36 | ESSGAsGDKDH | HPRD | |
| S140 | RPSLPsSPSPG | PhosphoSitePlus; HPRD | |
| S187 | PPVVSsTNEGS | HPRD | |
| S169 | QPPVVsSTNEG | HPRD | |
| Y60 | DKDHLySTVCK | Paxillin | PhosphoSitePlus |
| T16 | PAEPLtPPPSY | HPRD | |
| S137 | DKKRPsLPSSP | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S124 | PSLPSsPSPGL | HPRD | |
| Y38 | TPPPSyGHQPQ | Paxillin | PhosphoSitePlus |
| S105 | SSKVAsGEQKE | HPRD | |
| S123 | RPSLPsSPSPG | HPRD | |
| T44 | GHQPQtGSGES | HPRD | |
| S61 | KDHLYsTVCKP | Paxillin | PhosphoSitePlus |
| S65 | PPFSSsSGVLG | HPRD | |
| S194 | NEGSPsPPEPT | PhosphoSitePlus; HPRD | |
| T33 | PAEPLtPPPSY | Paxillin | PhosphoSitePlus |
| Y60 | DKDHLySTVCK | PYK2 | RegPhos |
| T27 | GHQPQtGSGES | HPRD | |
| T188 | PVVSStNEGSP | phosphoELM; RegPhos | |
| T62 | DHLYStVCKPR | Paxillin | PhosphoSitePlus |
| S175 | STNEGsPSPPE | HPRD | |
| S49 | TGSGEsSGASG | HPRD | |
| S170 | PPVVSsTNEGS | HPRD | |
| S126 | LPSSPsPGLPK | HPRD | |
| Y60 | DKDHLySTVCK | Fyn | phosphoELM; RegPhos |
| S68 | VCKPRsPKPAA | Paxillin | PhosphoSitePlus |
| T33 | PAEPLtPPPSY | HPRD; phosphoELM; RegPhos | |
| Y60 | DKDHLySTVCK | FYN | RegPhos |
| Y38 | TPPPSyGHQPQ | RegPhos | |
| S122 | SSKVAsGEQKE | HPRD; phosphoELM; RegPhos | |
| S37 | LTPPPsYGHQP | Paxillin | PhosphoSitePlus |
| S386 | HARRGsLCATC | HPRD | |
| S120 | DKKRPsLPSSP | HPRD | |
| S53 | ESSGAsGDKDH | HPRD | |
| S51 | VCKPRsPKPAA | HPRD | |
| S192 | STNEGsPSPPE | PhosphoSitePlus; HPRD | |
| S68 | VCKPRsPKPAA | HPRD; phosphoELM; RegPhos | |
| S177 | NEGSPsPPEPT | HPRD | |
| S82 | PPFSSsSGVLG | HPRD | |
| S122 | SSKVAsGEQKE | Paxillin | PhosphoSitePlus |
| S403 | HARRGsLCATC | PhosphoSitePlus; HPRD | |
| S32 | TGSGEsSGASG | HPRD | |
| S143 | LPSSPsPGLPK | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S141 | PSLPSsPSPGL | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| TGFI1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000378327 | S136L | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000378332 | Prostate Cancer | Metastasis | tissue | Down | 0.38 | 18553995 |
| Hyperphosphorylation site |
| TGFI1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| BTK_HUMAN | TGFI1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FYN_HUMAN | TGFI1_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| DMPK_HUMAN | TGFI1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FAK2_HUMAN | TGFI1_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| ZAGL2_HUMAN | TGFI1_HUMAN | kinase -> substrate | RegPhos |
| KPCA_HUMAN | TGFI1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| TGFI1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0030855 | epithelial cell differentiation | IEA | biological_process |
| GO:0005856 | cytoskeleton | IEA | cellular_component |
| GO:0008285 | negative regulation of cell proliferation | TAS | biological_process |
| GO:0070411 | I-SMAD binding | IEA | molecular_function |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0005622 | intracellular | IDA | cellular_component |
| GO:0003713 | transcription coactivator activity | IDA | molecular_function |
| GO:0030579 | ubiquitin-dependent SMAD protein catabolic process | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0016331 | morphogenesis of embryonic epithelium | IEA | biological_process |
| GO:0010718 | positive regulation of epithelial to mesenchymal t | IDA | biological_process |
| GO:0045599 | negative regulation of fat cell differentiation | IEA | biological_process |
| GO:0016363 | nuclear matrix | IEA | cellular_component |
| GO:0050681 | androgen receptor binding | IPI | molecular_function |
| GO:0030511 | positive regulation of transforming growth factor | IDA | biological_process |
| GO:0030512 | negative regulation of transforming growth factor | IDA | biological_process |
| GO:0007155 | cell adhesion | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0031012 | extracellular matrix | IDA | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005925 | focal adhesion | IEA | cellular_component |
| GO:0030521 | androgen receptor signaling pathway | NAS | biological_process |
| GO:0048495 | Roundabout binding | IPI | molecular_function |
| GO:0009408 | response to heat | IEA | biological_process |
| GO:0016055 | Wnt receptor signaling pathway | IEA | biological_process |
| GO:0045165 | cell fate commitment | IEA | biological_process |