Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TGFI1_HUMAN
Description:transforming growth factor beta 1 induced transcript 1 [Source:HGNC Symbol;Acc:11767]
Location:chr16 p11.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S186QPPVVsSTNEGHPRD
S36ESSGAsGDKDHHPRD
S140RPSLPsSPSPGPhosphoSitePlus; HPRD
S187PPVVSsTNEGSHPRD
S169QPPVVsSTNEGHPRD
Y60DKDHLySTVCKPaxillinPhosphoSitePlus
T16PAEPLtPPPSYHPRD
S137DKKRPsLPSSPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S124PSLPSsPSPGLHPRD
Y38TPPPSyGHQPQPaxillinPhosphoSitePlus
S105SSKVAsGEQKEHPRD
S123RPSLPsSPSPGHPRD
T44GHQPQtGSGESHPRD
S61KDHLYsTVCKPPaxillinPhosphoSitePlus
S65PPFSSsSGVLGHPRD
S194NEGSPsPPEPTPhosphoSitePlus; HPRD
T33PAEPLtPPPSYPaxillinPhosphoSitePlus
Y60DKDHLySTVCKPYK2RegPhos
T27GHQPQtGSGESHPRD
T188PVVSStNEGSPphosphoELM; RegPhos
T62DHLYStVCKPRPaxillinPhosphoSitePlus
S175STNEGsPSPPEHPRD
S49TGSGEsSGASGHPRD
S170PPVVSsTNEGSHPRD
S126LPSSPsPGLPKHPRD
Y60DKDHLySTVCKFynphosphoELM; RegPhos
S68VCKPRsPKPAAPaxillinPhosphoSitePlus
T33PAEPLtPPPSYHPRD; phosphoELM; RegPhos
Y60DKDHLySTVCKFYNRegPhos
Y38TPPPSyGHQPQRegPhos
S122SSKVAsGEQKEHPRD; phosphoELM; RegPhos
S37LTPPPsYGHQPPaxillinPhosphoSitePlus
S386HARRGsLCATCHPRD
S120DKKRPsLPSSPHPRD
S53ESSGAsGDKDHHPRD
S51VCKPRsPKPAAHPRD
S192STNEGsPSPPEPhosphoSitePlus; HPRD
S68VCKPRsPKPAAHPRD; phosphoELM; RegPhos
S177NEGSPsPPEPTHPRD
S82PPFSSsSGVLGHPRD
S122SSKVAsGEQKEPaxillinPhosphoSitePlus
S403HARRGsLCATCPhosphoSitePlus; HPRD
S32TGSGEsSGASGHPRD
S143LPSSPsPGLPKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S141PSLPSsPSPGLPhosphoSitePlus; HPRD

Dephosphorylation site
TGFI1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000378327S136LCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000378332Prostate CancerMetastasistissueDown0.3818553995

Hyperphosphorylation site
TGFI1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
BTK_HUMANTGFI1_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANTGFI1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
DMPK_HUMANTGFI1_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANTGFI1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANTGFI1_HUMANkinase -> substrateRegPhos
KPCA_HUMANTGFI1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
TGFI1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030855epithelial cell differentiationIEAbiological_process
GO:0005856cytoskeletonIEAcellular_component
GO:0008285negative regulation of cell proliferationTASbiological_process
GO:0070411I-SMAD bindingIEAmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0005622intracellularIDAcellular_component
GO:0003713transcription coactivator activityIDAmolecular_function
GO:0030579ubiquitin-dependent SMAD protein catabolic processIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0016331morphogenesis of embryonic epitheliumIEAbiological_process
GO:0010718positive regulation of epithelial to mesenchymal tIDAbiological_process
GO:0045599negative regulation of fat cell differentiationIEAbiological_process
GO:0016363nuclear matrixIEAcellular_component
GO:0050681androgen receptor bindingIPImolecular_function
GO:0030511positive regulation of transforming growth factor IDAbiological_process
GO:0030512negative regulation of transforming growth factor IDAbiological_process
GO:0007155cell adhesionTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0031012extracellular matrixIDAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0005925focal adhesionIEAcellular_component
GO:0030521androgen receptor signaling pathwayNASbiological_process
GO:0048495Roundabout bindingIPImolecular_function
GO:0009408response to heatIEAbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0045165cell fate commitmentIEAbiological_process


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