| UniProt/SwissProt ID: | SYUB_HUMAN |
| Description: | synuclein, beta [Source:HGNC Symbol;Acc:11140] |
| Location: | chr5 q35.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S118 | EPEGEsYEDPP | CK2_group | RegPhos |
| S118 | EPEGEsYEDPP | GRK5 | HPRD |
| Y127 | PPQEEyQEYEP | PhosphoSitePlus | |
| S118 | EPEGEsYEDPP | Synuclein | PhosphoSitePlus |
| S118 | EPEGEsYEDPP | BARK1 | RegPhos |
| S118 | EPEGEsYEDPP | GPRK5 | RegPhos |
| Y39 | KEGVLyVGSKT | Synuclein | PhosphoSitePlus |
| S118 | EPEGEsYEDPP | GPRK5(GRK5 | RegPhos |
| Dephosphorylation site |
| SYUB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000377296 | E109K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000377296 | G82R | COSMIC | Head and Neck Cancer | 21984974 |
| Differential expressed protein |
| SYUB_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SYUB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ARBK1_HUMAN | SYUB_HUMAN | kinase -> substrate | RegPhos |
| GRK5_HUMAN | SYUB_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| SYUB_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0050808 | synapse organization | IEA | biological_process |
| GO:0043025 | neuronal cell body | IEA | cellular_component |
| GO:0004859 | phospholipase inhibitor activity | TAS | molecular_function |
| GO:0043195 | terminal button | IEA | cellular_component |
| GO:0007268 | synaptic transmission | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005509 | calcium ion binding | IDA | molecular_function |
| GO:0043014 | alpha-tubulin binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0030426 | growth cone | IEA | cellular_component |
| GO:0043524 | negative regulation of neuron apoptotic process | IEA | biological_process |
| GO:0043679 | axon terminus | IEA | cellular_component |
| GO:0048487 | beta-tubulin binding | IEA | molecular_function |
| GO:0042417 | dopamine metabolic process | IEA | biological_process |
| GO:0045202 | synapse | IEA | cellular_component |