Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SHPS1_HUMAN
Description:signal-regulatory protein alpha [Source:HGNC Symbol;Acc:9662]
Location:chr20 p13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y495PSFSEyASVQVJAK2RegPhos
Y496PSFSEyASVQVPhosphoSitePlus; HPRD
T469SEDTLtYADLDPhosphoSitePlus
Y453NNHTEyASIQTPhosphoSitePlus
Y429TNDITyADLNLPhosphoSitePlus
Y428TNDITyADLNLTyr-kinases RegPhos
S204DPVGEsVSYSIC1-setPhosphoSitePlus
S192NGNELsDFQTNC1-setPhosphoSitePlus
Y495PSFSEyASVQVTyr-kinases RegPhos
T428DTNDItYADLNPhosphoSitePlus
S464SPQPAsEDTLTPhosphoSitePlus
Y496PSFSEyASVQVJAK2HPRD
T467PASEDtLTYADPhosphoSitePlus
S494PEPSFsEYASVPhosphoSitePlus
Y470EDTLTyADLDMPhosphoSitePlus
Y452NNHTEyASIQTTyr-kinases RegPhos
Y469EDTLTyADLDMTyr-kinases RegPhos

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y453EPNNHTEyASIQTSPPTPN11HPRD
Y453EPNNHTEyASIQTSPPTPN6HPRD
Y496PEPSFSEyASVQVPRPTPN11HPRD
Y429QDTNDITyADLNLPKPTPN11HPRD
Y470ASEDTLTyADLDMVHPTPN11HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000351621V302ITCGAOvarian Cancer21720365, 18772890
ENSP00000348307N100DBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000351621V302ICOSMICOvarian Cancer21720365
ENSP00000348307V302ICOSMICOvarian Cancer21720365
ENSP00000348307V302ITCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000351621Testicular CancerNormal vs. Cancercell lineUp18489135
ENSP00000351621Uterine CancerNormal vs. CancertissueDown16051329
ENSP00000351621Uterine CancerNormal vs. CancertissueDown19771267

Hyperphosphorylation site
SHPS1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
JAK2_HUMANSHPS1_HUMANkinase -> substrateHPRD; RegPhos
PTN11_HUMANSHPS1_HUMANphosphatase -> substrateHPRD
PTN6_HUMANSHPS1_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04380Osteoclast differentiation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005886plasma membraneTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0007155cell adhesionTASbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0016020membraneTAScellular_component
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0007596blood coagulationTASbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23