Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HHIP_HUMAN
Description:hedgehog interacting protein [Source:HGNC Symbol;Acc:14866]
Location:chr4 q31.21
Node attribute:receptor; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y265IFKEPyLDIHKPhosphoSitePlus
S626GKCCCsPGWEGPhosphoSitePlus
Y616LCRNGyCTPTGPhosphoSitePlus
T620GYCTPtGKCCCPhosphoSitePlus
T618RNGYCtPTGKCPhosphoSitePlus
Y293AFHPNyKKNGKPhosphoSitePlus

Dephosphorylation site
HHIP_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000296575H214QBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000296575D513NBIOMARTchronic lymphocytic leukemia21930507, 21930502
ENSP00000296575F180VCOSMICMelanoma21499247
ENSP00000296575P409QTCGAOvarian Cancer21720365, 18772890
ENSP00000296575P409QCOSMICOvarian Cancer21720365
ENSP00000296575A601fs*4COSMICCentral Nervous System Neoplasms18772396
ENSP00000296575S568NCOSMICHead and Neck Cancer21798897
ENSP00000296575G577ECOSMICMelanoma21499247

Differential expressed protein
HHIP_HUMAN is not differential expressed protein.

Hyperphosphorylation site
HHIP_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DHH_HUMANHHIP_HUMANligand -> receptorHPMR
IHH_HUMANHHIP_HUMANligand -> receptorHPMR
SHH_HUMANHHIP_HUMANligand -> receptorHPMR
HHIP_HUMANIHH_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa04340Hedgehog signaling pathway
hsa05217Basal cell carcinoma

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003824catalytic activityIEAmolecular_function
GO:0005887integral to plasma membraneISScellular_component
GO:0009968negative regulation of signal transductionIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0048705skeletal system morphogenesisISSbiological_process
GO:0048705skeletal system morphogenesisIEAbiological_process
GO:0005975carbohydrate metabolic processIEAbiological_process
GO:0060441epithelial tube branching involved in lung morphogIEAbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0040036regulation of fibroblast growth factor receptor siIEAbiological_process
GO:0009887organ morphogenesisIEAbiological_process
GO:0097108hedgehog family protein bindingIPImolecular_function
GO:0007224smoothened signaling pathwayIEAbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0045879negative regulation of smoothened signaling pathwaISSbiological_process
GO:0007405neuroblast proliferationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045879negative regulation of smoothened signaling pathwaIEAbiological_process
GO:0009953dorsal/ventral pattern formationIEAbiological_process
GO:0016901oxidoreductase activity, acting on the CH-OH groupIEAmolecular_function
GO:0048038quinone bindingIEAmolecular_function
GO:0005887integral to plasma membraneIEAcellular_component
GO:0008270zinc ion bindingIDAmolecular_function


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