Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FIP1_HUMAN
Description:FIP1 like 1 (S. cerevisiae) [Source:HGNC Symbol;Acc:19124]
Location:chr4 q12
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y27EEEWLyGGPWDPhosphoSitePlus
S443APSWPsLVDTSPhosphoSitePlus
T588PEQEStEATPHPRD
S274PPSRNsTSSQSPhosphoSitePlus
T283QSQTStASRKAPhosphoSitePlus
Y510YRYREyAERGYPhosphoSitePlus
Y110TGAPQyGSYGTPhosphoSitePlus; phosphoELM
T494RDHSPtPSVFNPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S559SEEGDsHRRHKPhosphoSitePlus; HPRD
S440PGSAPsWPSLVPhosphoSitePlus
S14LVSELsGGTGGHPRD
T482RERERtRERERPhosphoSitePlus; HPRD
Y505SDEERyRYREYPhosphoSitePlus; HPRD
S554RRRHEsEEGDSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T221CTMEVtPGAEIPhosphoSitePlus
S579GKEAGsEPAPEPhosphoSitePlus; HPRD
S262FTSPPsLFKTGHPRD
S85ETEDDsDSDSDPhosphoSitePlus; HPRD; phosphoELM
S277RNSTSsQSQTSPhosphoSitePlus
S587APEQEsTEATPHPRD
T591ESTEAtPAE__PhosphoSitePlus
S548SSRSNsRRRHEPhosphoSitePlus; HPRD
S89DSDSDsDDDEDPhosphoSitePlus; HPRD; phosphoELM
Y113PQYGSyGTAPVPhosphoSitePlus; phosphoELM
S112APQYGsYGTAPPhosphoSitePlus
T281SSQSQtSTASRPhosphoSitePlus
Y454KQWDYyARREKPhosphoSitePlus
Y453SKQWDyYARREPhosphoSitePlus
S259KAEFTsPPSLFPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T81PKVTEtEDDSDHPRD; phosphoELM
T99DDVHVtIGDIKHPRD
S304YGRAEsPDLRRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y515YAERGyERHRAPhosphoSitePlus
Y175ADLSDyFNYGFFip1PhosphoSitePlus
Y129TGGRVyGTTGTPhosphoSitePlus
S492RERDHsPTPSVPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T79PKPKVtETEDDHPRD; phosphoELM
Y426ARAFPyGNVAFPhosphoSitePlus; phosphoELM
Y299KWQDRyGRAESHPRD
S496HSPTPsVFNSDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S279STSSQsQTSTAPhosphoSitePlus
S37DVHVHsDLAKDPhosphoSitePlus
S87EDDSDsDSDDDPhosphoSitePlus; HPRD; phosphoELM
S500PSVFNsDEERYPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
FIP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000336752W165RCOSMICOvarian Cancer21720365
ENSP00000336752E45GCOSMICHepatocellular Carcinoma21822264
ENSP00000336752V6ICOSMICMelanoma

Differential expressed protein
FIP1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FIP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANFIP1_HUMANkinase -> substrateRobert H Newman (2013)
SGK3_HUMANFIP1_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANFIP1_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANFIP1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
FIP1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005524ATP bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0005847mRNA cleavage and polyadenylation specificity factIEAcellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0004714transmembrane receptor protein tyrosine kinase actIEAmolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0006397mRNA processingIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0004672protein kinase activityIEAmolecular_function


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23