UniProt/SwissProt ID: | SDC2_HUMAN |
Description: | syndecan 2 [Source:HGNC Symbol;Acc:10659] |
Location: | chr8 q22.1 |
Node attribute: | receptor; substrate |
Phosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
Y200 | PTKEF | HPRD | |
S41 | SIEEAsGVYPI | Syndecan | PhosphoSitePlus |
S188 | ERKPSsAAYQK | PKC_group | phosphoELM; RegPhos |
S187 | GERKPsSAAYQ | Glycophorin_A; Herpes_gE; | PhosphoSitePlus |
T196 | YQKAPtKEFYA | Herpes_gE; Syndecan; Prot | PhosphoSitePlus |
S188 | ERKPSsAAYQK | PKCg | RegPhos |
Y191 | PSSAAyQKAPT | Glycophorin_A; Herpes_gE; | PhosphoSitePlus |
S187 | GERKPsSAAYQ | PKCa | RegPhos |
S187 | GERKPsSAAYQ | PKCb | RegPhos |
S187 | GERKPsSAAYQ | PKCg | RegPhos |
Y200 | PTKEFyA____ | Herpes_gE | PhosphoSitePlus |
S187 | GERKPsSAAYQ | PKC_group | phosphoELM; RegPhos |
S188 | ERKPSsAAYQK | PKCa | RegPhos |
S188 | ERKPSsAAYQK | PKCb | RegPhos |
S187 | GERKPsSAAYQ | PRKCG | HPRD |
S187 | GERKPsSAAYQ | PRKCB | HPRD |
Y191 | PSSAAyQKAPT | HPRD | |
Y179 | KDEGSyDLGER | Glycophorin_A; Herpes_gE; | PhosphoSitePlus |
S188 | ERKPSsAAYQK | PRKCA | HPRD |
S188 | ERKPSsAAYQK | PRKCB | HPRD |
S188 | ERKPSsAAYQK | PRKCG | HPRD |
S187 | GERKPsSAAYQ | PRKCA | HPRD |
S188 | ERKPSsAAYQK | Glycophorin_A; Herpes_gE; | PhosphoSitePlus |
Dephosphorylation site |
SDC2_HUMAN do not have dephosphorylation site. |
Mutation site |
Ensembl ID | Variation | Source | Cancer name | Pubmed |
---|---|---|---|---|
ENSP00000307046 | V43G | COSMIC | Ovarian Cancer | 21720365 |
ENSP00000307046 | V43G | TCGA | Ovarian Cancer | 21720365, 18772890 |
ENSP00000307046 | D108N | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000441453 | V43G | TCGA | Ovarian Cancer | 21720365, 18772890 |
ENSP00000307046 | E125K | TCGA | Ovarian Cancer | 21720365, 18772890 |
ENSP00000441453 | E125K | TCGA | Ovarian Cancer | 21720365, 18772890 |
ENSP00000307046 | E125K | COSMIC | Ovarian Cancer | 21720365 |
Differential expressed protein |
SDC2_HUMAN is not differential expressed protein. |
Hyperphosphorylation site |
SDC2_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Source | Target | Relationship | Resource |
---|---|---|---|
FGF2_HUMAN | SDC2_HUMAN | ligand -> receptor | HPMR |
KPCA_HUMAN | SDC2_HUMAN | kinase -> substrate | HPRD |
KPCB_HUMAN | SDC2_HUMAN | kinase -> substrate | HPRD |
KPCG_HUMAN | SDC2_HUMAN | kinase -> substrate | HPRD |
Function Annotation |
KEGG Pathway |
KEGG ID | Pathway |
---|---|
hsa04514 | Cell adhesion molecules (CAMs) |
hsa04512 | ECM-receptor interaction |
hsa05144 | Malaria |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0030165 | PDZ domain binding | IPI | molecular_function |
GO:0005886 | plasma membrane | TAS | cellular_component |
GO:0005975 | carbohydrate metabolic process | TAS | biological_process |
GO:0048814 | regulation of dendrite morphogenesis | ISS | biological_process |
GO:0005887 | integral to plasma membrane | NAS | cellular_component |
GO:0048813 | dendrite morphogenesis | IEA | biological_process |
GO:0008092 | cytoskeletal protein binding | IEA | molecular_function |
GO:0031000 | response to caffeine | IEA | biological_process |
GO:0006027 | glycosaminoglycan catabolic process | TAS | biological_process |
GO:0030203 | glycosaminoglycan metabolic process | TAS | biological_process |
GO:0005515 | protein binding | IEA | molecular_function |
GO:0016021 | integral to membrane | IEA | cellular_component |
GO:0030204 | chondroitin sulfate metabolic process | TAS | biological_process |
GO:0044281 | small molecule metabolic process | TAS | biological_process |
GO:0043202 | lysosomal lumen | TAS | cellular_component |
GO:0042060 | wound healing | IEA | biological_process |
GO:0043025 | neuronal cell body | IEA | cellular_component |
GO:0001666 | response to hypoxia | IEA | biological_process |
GO:0005796 | Golgi lumen | TAS | cellular_component |
GO:0006024 | glycosaminoglycan biosynthetic process | TAS | biological_process |
GO:0008150 | biological_process | ND | biological_process |
GO:0016020 | membrane | IEA | cellular_component |
GO:0005515 | protein binding | IPI | molecular_function |