Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:S1PR1_HUMAN
Description:sphingosine-1-phosphate receptor 1 [Source:HGNC Symbol;Acc:3165]
Location:chr1 p21.2
Node attribute:substrate; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S129MFVALsASVFSTM; 7tm_1PhosphoSitePlus
T236RSRRLtFRKNI7tm_1PhosphoSitePlus
T236RSRRLtFRKNIPKB_groupphosphoELM
T236RSRRLtFRKNIAKT1HPRD

Dephosphorylation site
S1PR1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000305416V50LBIOMARTBreast Cancer21930507, 21930502
ENSP00000305416S44RCOSMICOvarian Cancer21720365
ENSP00000305416D356YCOSMICLung Cancer20668451
ENSP00000305416F340LBIOMARTBreast Cancer21930507, 21930502
ENSP00000305416V264ICOSMICOvarian Cancer21720365
ENSP00000305416A267TCOSMICHead and Neck Cancer21798893
ENSP00000305416V264ITCGAOvarian Cancer21720365, 18772890

Differential expressed protein
S1PR1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
S1PR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PPA6_HUMANS1PR1_HUMANligand -> receptorHPMR
AKT1_HUMANS1PR1_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANS1PR1_HUMANkinase -> substrateRegPhos
GLHA_HUMANS1PR1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046625sphingolipid bindingIEAmolecular_function
GO:0038036sphingosine-1-phosphate receptor activityIEAmolecular_function
GO:0007193adenylate cyclase-inhibiting G-protein coupled recIEAbiological_process
GO:0051482elevation of cytosolic calcium ion concentration iIEAbiological_process
GO:0051497negative regulation of stress fiber assemblyIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0045446endothelial cell differentiationIEAbiological_process
GO:0007420brain developmentIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0004930G-protein coupled receptor activityTASmolecular_function
GO:0001525angiogenesisIEAbiological_process
GO:0030155regulation of cell adhesionIEAbiological_process
GO:0048661positive regulation of smooth muscle cell proliferIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0019226transmission of nerve impulseIEAbiological_process
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0030182neuron differentiationIEAbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0007155cell adhesionTASbiological_process
GO:0032320positive regulation of Ras GTPase activityIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0050927positive regulation of positive chemotaxisIEAbiological_process


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