Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RHOC_HUMAN
Description:ras homolog family member C [Source:HGNC Symbol;Acc:669]
Location:chr1 p13.2
Node attribute:effector

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y156ISAFGyLECSARasPhosphoSitePlus
Y34QFPEVyVPTVFRasPhosphoSitePlus
Y66AGQEDyDRLRPRasPhosphoSitePlus

Dephosphorylation site
RHOC_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000358651D59ECOSMICOvarian Cancer21720365
ENSP00000345236D59ECOSMICOvarian Cancer21720365
ENSP00000345236E125QCOSMICHead and Neck Cancer21798893
ENSP00000358647E125QCOSMICHead and Neck Cancer21798893
ENSP00000358652D59ECOSMICOvarian Cancer21720365
ENSP00000285735E125QCOSMICHead and Neck Cancer21798893
ENSP00000358646D59ECOSMICOvarian Cancer21720365
ENSP00000358656D59ECOSMICOvarian Cancer21720365
ENSP00000358652E125QCOSMICHead and Neck Cancer21798893
ENSP00000358647D59ECOSMICOvarian Cancer21720365
ENSP00000358651E125QCOSMICHead and Neck Cancer21798893
ENSP00000358646E125QCOSMICHead and Neck Cancer21798893
ENSP00000358656E125QCOSMICHead and Neck Cancer21798893
ENSP00000285735D59ECOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000358647Gastric CancerMetastasiscell lineDown0.5417022644
ENSP00000358647Gastric CancerMetastasiscell lineDown0.5417022644
ENSP00000358647Testicular CancerNormal vs. Cancercell lineDown18489135
ENSP00000358647Ovarian CancerTreatment (chemotherapy-sensitive vs. chemotherapy-resistant)tissueUp1019422301

Hyperphosphorylation site
RHOC_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBB2_HUMANRHOC_HUMANGprotein -> effectorgpDB
GBG8_HUMANRHOC_HUMANGprotein -> effectorgpDB
GBG1_HUMANRHOC_HUMANGprotein -> effectorgpDB
GBG2_HUMANRHOC_HUMANGprotein -> effectorgpDB
GBG10_HUMANRHOC_HUMANGprotein -> effectorgpDB
GBB3_HUMANRHOC_HUMANGprotein -> effectorgpDB
GBG11_HUMANRHOC_HUMANGprotein -> effectorgpDB
GBG5_HUMANRHOC_HUMANGprotein -> effectorgpDB
GBB1_HUMANRHOC_HUMANGprotein -> effectorgpDB
GBG3_HUMANRHOC_HUMANGprotein -> effectorgpDB
GBB5_HUMANRHOC_HUMANGprotein -> effectorgpDB
GBG13_HUMANRHOC_HUMANGprotein -> effectorgpDB
GBG12_HUMANRHOC_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
RHOC_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0006184GTP catabolic processIEAbiological_process
GO:0005525GTP bindingIEAmolecular_function
GO:0005829cytosolIEAcellular_component
GO:0003924GTPase activityIEAmolecular_function
GO:0043297apical junction assemblyIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0015031protein transportIEAbiological_process
GO:0033205cell cycle cytokinesisIDAbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIMPbiological_process
GO:0016020membraneIEAcellular_component
GO:0007264small GTPase mediated signal transductionIEAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0004871signal transducer activityIMPmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0032154cleavage furrowIDAcellular_component


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