Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RGS19_HUMAN
Description:regulator of G-protein signaling 19 [Source:HGNC Symbol;Acc:13735]
Location:chr20 q13.33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S214GPSQSsSEA__PhosphoSitePlus; SysPTM
S24RPPSMsSHDTAPKC_groupRegPhos
S213QGPSQsSSEA_PhosphoSitePlus; SysPTM
S148YEDYVsILSPKRGSPhosphoSitePlus
S214GPSQSsSHPRD; SysPTM
Y146LIYEDyVSILSRGSPhosphoSitePlus
S215PSQSSsHPRD; SysPTM
S97DKLMHsPAGRSHPRD; SysPTM
S24RPPSMsSHDTACK2a2RegPhos
S213QGPSQsSSHPRD; SysPTM
S151YVSILsPKEVSErk1(MAPK3RegPhos
S97DKLMHsPAGRSRGSPhosphoSitePlus; SysPTM
S24RPPSMsSHDTACK2_groupphosphoELM; RegPhos
T201FLSSPtYRALLRGSPhosphoSitePlus
S211LLQGPsQSSSEPhosphoSitePlus
S24RPPSMsSHDTAPKCaRegPhos
T201FLSSPtYRALLPKC_groupphosphoELM; RegPhos
S199PRFLSsPTYRARGSPhosphoSitePlus
S151YVSILsPKEVSRGSPhosphoSitePlus
S151YVSILsPKEVSErk2RegPhos
Y202LSSPTyRALLLRGSPhosphoSitePlus
S151YVSILsPKEVSMAPK1HPRD; phosphoELM
S24RPPSMsSHDTAPhosphoSitePlus; phosphoELM; RegPhos
Y143KARLIyEDYVSRGSPhosphoSitePlus
S24RPPSMsSHDTACK2a1RegPhos
S151YVSILsPKEVSCK2_groupphosphoELM; RegPhos
T201FLSSPtYRALLPRKCAHPRD
S151YVSILsPKEVSErk2(MAPK1RegPhos
T201FLSSPtYRALLPKCaRegPhos
S24RPPSMsSHDTACSNK2A2HPRD
S24RPPSMsSHDTACSNK2A1HPRD
S215PSQSSsEA___PhosphoSitePlus; SysPTM
S24RPPSMsSHDTAPRKCAHPRD
S24RPPSMsSHDTACK2a1-rsRegPhos

Dephosphorylation site
RGS19_HUMAN do not have dephosphorylation site.

Mutation site
RGS19_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000378483Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
RGS19_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANRGS19_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCA_HUMANRGS19_HUMANkinase -> substrateHPRD
CSK21_HUMANRGS19_HUMANkinase -> substrateHPRD
ZAGL2_HUMANRGS19_HUMANkinase -> substrateRegPhos
CSK22_HUMANRGS19_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
RGS19_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0005886plasma membraneIBAcellular_component
GO:0016020membraneTAScellular_component
GO:0005096GTPase activator activityIBAmolecular_function
GO:0005794Golgi apparatusTAScellular_component
GO:0038032termination of G-protein coupled receptor signalinIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0006914autophagyIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0044445cytosolic partIEAcellular_component
GO:0043547positive regulation of GTPase activityIBAbiological_process
GO:0001965G-protein alpha-subunit bindingIEAmolecular_function
GO:0005737cytoplasmIBAcellular_component
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030136clathrin-coated vesicleIEAcellular_component
GO:0005834heterotrimeric G-protein complexTAScellular_component
GO:0005903brush borderIEAcellular_component


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