| UniProt/SwissProt ID: | RBX2_HUMAN |
| Description: | ring finger protein 7 [Source:HGNC Symbol;Acc:10070] |
| Location: | chr3 q23 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T10 | EDGEEtCALAS | P67870(Casein kinase II ) | RegPhos |
| S15 | TCALAsHSGSS | PhosphoSitePlus | |
| T10 | EDGEEtCALAS | CSNK2B | HPRD |
| T10 | EDGEEtCALAS | CK2_alpha | phosphoELM |
| S31 | GDKMFsLKKWN | zf-rbx1 | PhosphoSitePlus |
| T10 | EDGEEtCALAS | PhosphoSitePlus | |
| T10 | EDGEEtCALAS | CK2a1(CK2 alpha | RegPhos |
| T10 | EDGEEtCALAS | CK2_group | phosphoELM; RegPhos |
| Dephosphorylation site |
| RBX2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000273480 | E79Q | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| RBX2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RBX2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CSK2B_HUMAN | RBX2_HUMAN | kinase -> substrate | HPRD |
| CSK21_HUMAN | RBX2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04120 | Ubiquitin mediated proteolysis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0043066 | negative regulation of apoptotic process | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0051775 | response to redox state | TAS | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0008631 | intrinsic apoptotic signaling pathway in response | TAS | biological_process |
| GO:0019788 | NEDD8 ligase activity | IDA | molecular_function |
| GO:0045116 | protein neddylation | IDA | biological_process |
| GO:0005507 | copper ion binding | TAS | molecular_function |
| GO:0016567 | protein ubiquitination | IEA | biological_process |
| GO:0031466 | Cul5-RING ubiquitin ligase complex | IDA | cellular_component |