Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RASN_HUMAN
Description:neuroblastoma RAS viral (v-ras) oncogene homolog [Source:HGNC Symbol;Acc:7989]
Location:chr1 p13.2
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S39PTIEDsYRKQVRas; Ldh_1_NPhosphoSitePlus
Y32HFVDEyDPTIERas; Ldh_1_NPhosphoSitePlus
Y64AGQEEySAMRDRasPhosphoSitePlus
Y157VEDAFyTLVRERasPhosphoSitePlus
T148ETSAKtRQGVERasPhosphoSitePlus

Dephosphorylation site
RASN_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000358548Q61ROMIMThyroid Carcinoma12727991
ENSP00000358548Q61LDing2008Prostate Cancer10766161, 11520807, 11699412, 12068308, 12429636, 12446472, 12873990, 12947056, 1323601, 14681681, 14737077, 14961576, 14982869, 15048078, 15252839, 15467732, 1585764, 15897885, 1598607, 16281072, 16404744, 16518851, 17119447, 17260012, 17332249, 17518771, 17535228, 18227705, 18428421, 18948947, 1996309, 2154325, 2197591, 2247846, 2564452, 2648253, 2659902, 2681517, 2682463, 7576742, 7597312, 7927179, 8026877, 8120410, 8161790, 8490179, 8780392, 9379676, 9680114, 9793966, 9804334, 9858914
ENSP00000358548Q61LBIOMARTLung Cancer21930507, 21930502
ENSP00000358548G12CHPILeukemia2998510 21724579 18024411 3330790
ENSP00000358548Q61LDing2008Lung Cancer10766161, 11520807, 11699412, 12068308, 12429636, 12446472, 12873990, 12947056, 1323601, 14681681, 14737077, 14961576, 14982869, 15048078, 15252839, 15467732, 1585764, 15897885, 1598607, 16281072, 16404744, 16518851, 17119447, 17260012, 17332249, 17518771, 17535228, 18227705, 18428421, 18948947, 1996309, 2154325, 2197591, 2247846, 2564452, 2648253, 2659902, 2681517, 2682463, 7576742, 7597312, 7927179, 8026877, 8120410, 8161790, 8490179, 8780392, 9379676, 9680114, 9793966, 9804334, 9858914
ENSP00000358548Q61LDing2008Thyroid Carcinoma10766161, 11520807, 11699412, 12068308, 12429636, 12446472, 12873990, 12947056, 1323601, 14681681, 14737077, 14961576, 14982869, 15048078, 15252839, 15467732, 1585764, 15897885, 1598607, 16281072, 16404744, 16518851, 17119447, 17260012, 17332249, 17518771, 17535228, 18227705, 18428421, 18948947, 1996309, 2154325, 2197591, 2247846, 2564452, 2648253, 2659902, 2681517, 2682463, 7576742, 7597312, 7927179, 8026877, 8120410, 8161790, 8490179, 8780392, 9379676, 9680114, 9793966, 9804334, 9858914
ENSP00000358548Q61LDing2008Neoplasms by Histologic Type10766161, 11520807, 11699412, 12068308, 12429636, 12446472, 12873990, 12947056, 1323601, 14681681, 14737077, 14961576, 14982869, 15048078, 15252839, 15467732, 1585764, 15897885, 1598607, 16281072, 16404744, 16518851, 17119447, 17260012, 17332249, 17518771, 17535228, 18227705, 18428421, 18948947, 1996309, 2154325, 2197591, 2247846, 2564452, 2648253, 2659902, 2681517, 2682463, 7576742, 7597312, 7927179, 8026877, 8120410, 8161790, 8490179, 8780392, 9379676, 9680114, 9793966, 9804334, 9858914
ENSP00000358548Q61RHPILung Cancer3276402 20925915 19880792 18814281 18679422 18205010 16818621 16555627 14508525
ENSP00000358548G13ROMIM, HPIColorectal Cancer3102434, 3102434 22199277 19880792
ENSP00000358548Q61LDing2008Liver Cancer10766161, 11520807, 11699412, 12068308, 12429636, 12446472, 12873990, 12947056, 1323601, 14681681, 14737077, 14961576, 14982869, 15048078, 15252839, 15467732, 1585764, 15897885, 1598607, 16281072, 16404744, 16518851, 17119447, 17260012, 17332249, 17518771, 17535228, 18227705, 18428421, 18948947, 1996309, 2154325, 2197591, 2247846, 2564452, 2648253, 2659902, 2681517, 2682463, 7576742, 7597312, 7927179, 8026877, 8120410, 8161790, 8490179, 8780392, 9379676, 9680114, 9793966, 9804334, 9858914
ENSP00000358548Q61LDing2008Other Cancer(urinary_tract cancer, ns cancer)10766161, 11520807, 11699412, 12068308, 12429636, 12446472, 12873990, 12947056, 1323601, 14681681, 14737077, 14961576, 14982869, 15048078, 15252839, 15467732, 1585764, 15897885, 1598607, 16281072, 16404744, 16518851, 17119447, 17260012, 17332249, 17518771, 17535228, 18227705, 18428421, 18948947, 1996309, 2154325, 2197591, 2247846, 2564452, 2648253, 2659902, 2681517, 2682463, 7576742, 7597312, 7927179, 8026877, 8120410, 8161790, 8490179, 8780392, 9379676, 9680114, 9793966, 9804334, 9858914
ENSP00000358548Q61LDing2008Skin Cancer10766161, 11520807, 11699412, 12068308, 12429636, 12446472, 12873990, 12947056, 1323601, 14681681, 14737077, 14961576, 14982869, 15048078, 15252839, 15467732, 1585764, 15897885, 1598607, 16281072, 16404744, 16518851, 17119447, 17260012, 17332249, 17518771, 17535228, 18227705, 18428421, 18948947, 1996309, 2154325, 2197591, 2247846, 2564452, 2648253, 2659902, 2681517, 2682463, 7576742, 7597312, 7927179, 8026877, 8120410, 8161790, 8490179, 8780392, 9379676, 9680114, 9793966, 9804334, 9858914

Differential expressed protein
RASN_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RASN_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
P53_HUMANRASN_HUMANTF -> target geneTRANSFAC
SP1_HUMANRASN_HUMANTF -> target geneTRANSFAC
NFIC_HUMANRASN_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
RASN_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007411axon guidanceTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0048169regulation of long-term neuronal synaptic plasticiIEAbiological_process
GO:0003924GTPase activityIEAmolecular_function
GO:0051146striated muscle cell differentiationIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0008542visual learningIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0000186activation of MAPKK activityTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0000165MAPK cascadeTASbiological_process
GO:0000139Golgi membraneIEAcellular_component
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0005525GTP bindingIEAmolecular_function
GO:0006184GTP catabolic processIEAbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0035022positive regulation of Rac protein signal transducIEAbiological_process
GO:0032228regulation of synaptic transmission, GABAergicIEAbiological_process
GO:0030036actin cytoskeleton organizationIEAbiological_process
GO:0015031protein transportIEAbiological_process
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0005622intracellularIEAcellular_component