Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RASA2_HUMAN
Description:RAS p21 protein activator 2 [Source:HGNC Symbol;Acc:9872]
Location:chr3 q23
Node attribute:PPI(source); effector; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y226FNEIFyFEVTRC2PhosphoSitePlus
S557GSLSKsKSSFKPhosphoSitePlus
Y785GTIAVyQGPQKPhosphoSitePlus
T544TLISKtIQTLGRasGAPPhosphoSitePlus
T537AQTIRtLTLISRasGAPPhosphoSitePlus
Y612KEGEMyKRAQGPHPhosphoSitePlus
Y107LSFYVyDKNVLC2PhosphoSitePlus
S217VKKKTsNPQFNC2PhosphoSitePlus
Y795KEPDDySNFVIPhosphoSitePlus
Y105QYLSFyVYDKNC2PhosphoSitePlus
S560SKSKSsFKETFPhosphoSitePlus
Y650GKDAIyTIPVKPHPhosphoSitePlus
T758DEDREtERIYSPhosphoSitePlus
T781EEACGtIAVYQPhosphoSitePlus

Dephosphorylation site
RASA2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000286364T136SCOSMICOvarian Cancer21720365
ENSP00000286364T136STCGAOvarian Cancer21720365, 18772890
ENSP00000286364R75HTCGAOvarian Cancer21720365, 18772890
ENSP00000286364R75HCOSMICOvarian Cancer21720365
ENSP00000286364Q708ECOSMICLung Cancer20668451
ENSP00000286364K774*BIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000286364K774RCOSMICBreast Cancer20668451
ENSP00000286364E759KCOSMICLung Cancer

Differential expressed protein
RASA2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RASA2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNA12_HUMANRASA2_HUMANGprotein -> effectorgpDB
GNA13_HUMANRASA2_HUMANGprotein -> effectorgpDB
RASA2_HUMANRRAS2_HUMANotherKEGG
GNA12_HUMANRASA2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway
hsa05203Viral carcinogenesis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIBAcellular_component
GO:0032320positive regulation of Ras GTPase activityIBAbiological_process
GO:0051056regulation of small GTPase mediated signal transduIEAbiological_process
GO:0046580negative regulation of Ras protein signal transducIBAbiological_process
GO:0031235intrinsic to internal side of plasma membraneIBAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0005543phospholipid bindingIEAmolecular_function
GO:0005099Ras GTPase activator activityIBAmolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0005099Ras GTPase activator activityIEAmolecular_function
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0007165signal transductionTASbiological_process
GO:0005096GTPase activator activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0043231intracellular membrane-bounded organelleIDAcellular_component


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