| UniProt/SwissProt ID: | RAD_HUMAN |
| Description: | Ras-related associated with diabetes [Source:HGNC Symbol;Acc:10446] |
| Location: | chr16 q22.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S214 | RSREVsVDEGR | Ras | PhosphoSitePlus |
| S257 | RLRRDsKEANA | PRKCA | HPRD |
| S257 | RLRRDsKEANA | PKCa | RegPhos |
| S257 | RLRRDsKEANA | PKCb | RegPhos |
| S273 | TRRREsLGKKA | CAMK2G | HPRD |
| S299 | AFRAKsKSCHD | PKCb | RegPhos |
| S299 | AFRAKsKSCHD | PKCa | RegPhos |
| S290 | IVARNsRKMAF | CSNK2A1 | HPRD |
| S299 | AFRAKsKSCHD | PRKCB | HPRD |
| S299 | AFRAKsKSCHD | PRKCA | HPRD |
| S257 | RLRRDsKEANA | PhosphoSitePlus | |
| S214 | RSREVsVDEGR | CK2a1 | RegPhos |
| S290 | IVARNsRKMAF | PKCb | RegPhos |
| S290 | IVARNsRKMAF | PKCa | RegPhos |
| S290 | IVARNsRKMAF | PRKCB | HPRD |
| S290 | IVARNsRKMAF | PRKCA | HPRD |
| S273 | TRRREsLGKKA | PRKACA | HPRD |
| S257 | RLRRDsKEANA | PRKACA | HPRD |
| S290 | IVARNsRKMAF | CK2a1 | RegPhos |
| S257 | RLRRDsKEANA | PRKCB | HPRD |
| S273 | TRRREsLGKKA | CK2a1-rs | RegPhos |
| S257 | RLRRDsKEANA | CSNK2A1 | HPRD |
| S257 | RLRRDsKEANA | PKACa | RegPhos |
| S290 | IVARNsRKMAF | CK2a1-rs | RegPhos |
| S290 | IVARNsRKMAF | PhosphoSitePlus | |
| S214 | RSREVsVDEGR | CK2_group | phosphoELM; RegPhos |
| S273 | TRRREsLGKKA | CK2a1 | RegPhos |
| S273 | TRRREsLGKKA | CaMK2g | RegPhos |
| S79 | EDSEDsLSSGG | PhosphoSitePlus | |
| S257 | RLRRDsKEANA | CK2a1-rs | RegPhos |
| S214 | RSREVsVDEGR | CK2a1-rs | RegPhos |
| S273 | TRRREsLGKKA | CSNK2A1 | HPRD |
| S214 | RSREVsVDEGR | CSNK2A1 | HPRD |
| S273 | TRRREsLGKKA | PKACa | RegPhos |
| S299 | AFRAKsKSCHD | PhosphoSitePlus | |
| S273 | TRRREsLGKKA | PhosphoSitePlus | |
| S39 | PLHRRsMPVDE | PhosphoSitePlus | |
| S214 | RSREVsVDEGR | PKCa | RegPhos |
| S214 | RSREVsVDEGR | PKCb | RegPhos |
| S301 | RAKSKsCHDLS | PhosphoSitePlus | |
| S214 | RSREVsVDEGR | PRKCB | HPRD |
| S214 | RSREVsVDEGR | PRKCA | HPRD |
| S257 | RLRRDsKEANA | CK2a1 | RegPhos |
| Dephosphorylation site |
| RAD_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000388744 | *309Y | COSMIC | Intestines Cancer | 17932254 | ENSP00000299759 | *309Y | COSMIC | Intestines Cancer | 17932254 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000388744 | Breast Cancer | Normal vs. Cancer | tissue | Up | 18257521 | |
| Hyperphosphorylation site |
| RAD_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KCC2G_HUMAN | RAD_HUMAN | kinase -> substrate | HPRD |
| KPCA_HUMAN | RAD_HUMAN | kinase -> substrate | HPRD |
| CSK21_HUMAN | RAD_HUMAN | kinase -> substrate | HPRD |
| KPCB_HUMAN | RAD_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| RAD_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0007264 | small GTPase mediated signal transduction | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005516 | calmodulin binding | IEA | molecular_function |
| GO:0006184 | GTP catabolic process | IEA | biological_process |
| GO:0015031 | protein transport | IEA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005622 | intracellular | IEA | cellular_component |