Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RAB5C_HUMAN
Description:RAB5C, member RAS oncogene family [Source:HGNC Symbol;Acc:9785]
Location:chr17 q21.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S140KADLAsKRAVERasPhosphoSitePlus
Y83AGQERyHSLAPRasPhosphoSitePlus
S85QERYHsLAPMYRasPhosphoSitePlus
S124LQRQAsPNIVIRasPhosphoSitePlus

Dephosphorylation site
RAB5C_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000377440R40HHPIColorectal Cancer16959974
ENSP00000345689R40HHPIColorectal Cancer16959974
ENSP00000345689R40HCOSMICIntestines Cancer16959974
ENSP00000377440R40HCOSMICIntestines Cancer16959974
ENSP00000377440G93RCOSMICMelanoma
ENSP00000345689G93RCOSMICMelanoma

Differential expressed protein
RAB5C_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RAB5C_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ANPRB_HUMANRAB5C_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANRAB5C_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
RAB5C_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005525GTP bindingIEAmolecular_function
GO:0005811lipid particleIDAcellular_component
GO:0006886intracellular protein transportIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0030100regulation of endocytosisIEAbiological_process
GO:0042470melanosomeIEAcellular_component
GO:0015031protein transportIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0006913nucleocytoplasmic transportIEAbiological_process
GO:0003924GTPase activityTASmolecular_function
GO:0007032endosome organizationIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0007264small GTPase mediated signal transductionIEAbiological_process
GO:0030139endocytic vesicleIEAcellular_component
GO:0031901early endosome membraneIEAcellular_component
GO:0006184GTP catabolic processTASbiological_process
GO:0019003GDP bindingIDAmolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0005737cytoplasmIEAcellular_component


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