| UniProt/SwissProt ID: | PTPRZ_HUMAN |
| Description: | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 [Source:HGNC Symbol;Acc:9685] |
| Location: | chr7 q31.32 |
| Node attribute: | kinase; receptor; phosphotase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y1762 | INIVAyDHSRV | Y_phosphatase | PhosphoSitePlus |
| Y1672 | QTAHFyLEDST | PhosphoSitePlus | |
| Y2179 | ATQDDyVLEVR | Y_phosphatase | PhosphoSitePlus |
| T2285 | LSLVStRQEEN | HPRD | |
| S2055 | EKNRTsSIIPV | Y_phosphatase | PhosphoSitePlus |
| T1421 | GEDGDtDDDGD | PhosphoSitePlus | |
| S2031 | QFQLLsQSNIQ | PhosphoSitePlus | |
| Y2276 | QYQFLyKVILS | Y_phosphatase | PhosphoSitePlus |
| T1668 | RKCFQtAHFYL | PhosphoSitePlus | |
| S2199 | PDSPIsKTFEL | Y_phosphatase | PhosphoSitePlus |
| Y1756 | KHKNRyINIVA | Y_phosphatase | PhosphoSitePlus |
| Dephosphorylation site |
| PTPRZ_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000377047 | N468I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000377047 | D1409Y | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000377047 | S1512F | COSMIC | Melanoma | 21499247 | ENSP00000377047 | S1204I | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000377047 | D2178N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000377047 | E1817fs*9 | COSMIC | Ovarian Cancer | 21720365 | ENSP00000377047 | I1783V | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000377047 | A1698V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000377047 | E625K | COSMIC | Skin Cancer | 21984974 | ENSP00000377047 | R469H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000377047 | S943F | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| PTPRZ_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PTPRZ_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PTN_HUMAN | PTPRZ_HUMAN | ligand -> receptor | HPMR |
| PTPRZ_HUMAN | GIT1_HUMAN | kinase -> substrate | KEGG |
| PTPRZ_HUMAN | RHG35_HUMAN | phosphatase -> substrate | HPRD |
| PTPRZ_HUMAN | ADDB_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05120 | Epithelial cell signaling in Helicobacter pylori i |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0006470 | protein dephosphorylation | TAS | biological_process |
| GO:0008330 | protein tyrosine/threonine phosphatase activity | NAS | molecular_function |
| GO:0007409 | axonogenesis | IEA | biological_process |
| GO:0004725 | protein tyrosine phosphatase activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0072534 | perineuronal net | IEA | cellular_component |
| GO:0005001 | transmembrane receptor protein tyrosine phosphatas | TAS | molecular_function |
| GO:0007417 | central nervous system development | TAS | biological_process |
| GO:0016791 | phosphatase activity | IEA | molecular_function |
| GO:0016311 | dephosphorylation | IEA | biological_process |
| GO:0005578 | proteinaceous extracellular matrix | IEA | cellular_component |