| UniProt/SwissProt ID: | PTPRE_HUMAN |
| Description: | protein tyrosine phosphatase, receptor type, E [Source:HGNC Symbol;Acc:9669] |
| Location: | chr10 q26.2 |
| Node attribute: | phosphotase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S80 | RKAVVsTSDKK | PhosphoSitePlus | |
| Y696 | DIFSDyANFK_ | PhosphoSitePlus | |
| T81 | KAVVStSDKKM | PhosphoSitePlus | |
| Y638 | DIFSDyAN | HPRD | |
| Y696 | DIFSDyAN | HPRD | |
| T434 | EFRKLtNVRIM | PhosphoSitePlus | |
| S694 | FIDIFsDYANF | PhosphoSitePlus | |
| Y679 | QTLEQyEFCYK | Y_phosphatase | PhosphoSitePlus |
| Dephosphorylation site |
| PTPRE_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000254667 | E200K | COSMIC | Melanoma | 19074898 | ENSP00000402337 | E200K | COSMIC | Melanoma | 19074898 | ENSP00000402337 | G11D | COSMIC | Melanoma | 19074898 | ENSP00000254667 | G11D | COSMIC | Melanoma | 19074898 |
| Differential expressed protein |
| PTPRE_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PTPRE_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PTPRE_HUMAN | SRC_HUMAN | phosphatase -> substrate | HPRD |
| PTPRE_HUMAN | MK01_HUMAN | phosphatase -> substrate | HPRD |
| PTPRE_HUMAN | KCNB1_HUMAN | phosphatase -> substrate | HPRD |
| PTPRE_HUMAN | INSR_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| PTPRE_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0005001 | transmembrane receptor protein tyrosine phosphatas | TAS | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0045111 | intermediate filament cytoskeleton | IDA | cellular_component |
| GO:0016311 | dephosphorylation | IEA | biological_process |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0004725 | protein tyrosine phosphatase activity | IEA | molecular_function |
| GO:0016791 | phosphatase activity | IEA | molecular_function |
| GO:0033003 | regulation of mast cell activation | IEA | biological_process |
| GO:0007185 | transmembrane receptor protein tyrosine phosphatas | IEA | biological_process |
| GO:0046627 | negative regulation of insulin receptor signaling | ISS | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0042803 | protein homodimerization activity | IEA | molecular_function |
| GO:0046627 | negative regulation of insulin receptor signaling | IEA | biological_process |
| GO:0006470 | protein dephosphorylation | TAS | biological_process |