Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PTN18_HUMAN
Description:protein tyrosine phosphatase, non-receptor type 18 (brain-derived) [Source:HGNC Symbol;Acc:9649]
Location:chr2 q21.1
Node attribute:substrate; phosphotase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y389EEAPLySKVTPPhosphoSitePlus; HPRD
Y354AMADTyAVVQKPhosphoSitePlus
T376QTGTGtGTGARPhosphoSitePlus
T322ALFLRtPQALLPhosphoSitePlus
S390EAPLYsKVTPRPhosphoSitePlus
Y426AGSGAyEDVAGPhosphoSitePlus
T374GTQTGtGTGTGPhosphoSitePlus
Y354AMADTyAVVQKTECHPRD
T435AGGAQtGGLGFPhosphoSitePlus
Y281QTEEQyRFLYHTECHPRD; RegPhos
Y354AMADTyAEEQKTECRegPhos
Y424AGSGAyEDVAGRegPhos
S419VPADQsPAGSGPhosphoSitePlus
T393LYSKVtPRAQRPhosphoSitePlus
S423QSPAGsGAYEDPhosphoSitePlus
T458PPAEWtRV___PhosphoSitePlus
S10LDSARsFLERLPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T370GAGSGtQTGTGPhosphoSitePlus
Y303NASPHyQNIKETECHPRD; RegPhos
Y314NCAPLyDDALFPhosphoSitePlus
Y303NASPHyQNIKEPhosphoSitePlus
Y281QTEEQyRFLYHY_phosphatasePhosphoSitePlus
S345ISVPGsPGHAMPhosphoSitePlus
S76TRVILsLLQEEY_phosphatasePhosphoSitePlus
Y387EEAPLySKVTPphosphoELM; RegPhos

Dephosphorylation site
PTN18_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000175756A328PCOSMICRenal Cancer20054297
ENSP00000175756R331CCOSMICOvarian Cancer21720365
ENSP00000175756I74MCOSMICOvarian Cancer21720365
ENSP00000175756Y144HCOSMICOvarian Cancer21720365

Differential expressed protein
PTN18_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PTN18_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TEC_HUMANPTN18_HUMANkinase -> substrateRegPhos; NetPath
ZAGL2_HUMANPTN18_HUMANkinase -> substrateRegPhos
PTN18_HUMANTEC_HUMANphosphatase -> substrateNetPath
PTN18_HUMANFYN_HUMANphosphatase -> substrateHPRD
PTN18_HUMANSRC_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
PTN18_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016311dephosphorylationIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0004726non-membrane spanning protein tyrosine phosphataseIEAmolecular_function
GO:0006470protein dephosphorylationTASbiological_process
GO:0004725protein tyrosine phosphatase activityIEAmolecular_function
GO:0016791phosphatase activityIEAmolecular_function


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