Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PTH1R_HUMAN
Description:parathyroid hormone 1 receptor [Source:HGNC Symbol;Acc:9608]
Location:chr3 p21.31
Node attribute:GPCR; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y320FSEKKyLWGFT7tm_2PhosphoSitePlus
S73GWTSAsTSGKPPhosphoSitePlus
S492ARSGSsSYSYGPhosphoSitePlus
T99DKEAPtGSRYRPhosphoSitePlus
S101EAPTGsRYRGRPhosphoSitePlus
Y23VLSSAyALVDAPhosphoSitePlus
T192LGMIYtVGYSV7tm_2; TMPhosphoSitePlus

Dephosphorylation site
PTH1R_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000321999F238LCOSMICHepatocellular Carcinoma21822264

Differential expressed protein
PTH1R_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PTH1R_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PTHY_HUMANPTH1R_HUMANligand -> receptorHPMR
PTHR_HUMANPTH1R_HUMANligand -> receptorHPMR
PTH1R_HUMANGNAS2_HUMANGPCR -> GproteingpDB
PTH1R_HUMANGNAS1_HUMANGPCR -> GproteingpDB
GLHA_HUMANPTH1R_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04961Endocrine and other factor-regulated calcium reabs
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007189adenylate cyclase-activating G-protein coupled recIEAbiological_process
GO:0048469cell maturationIEAbiological_process
GO:0043235receptor complexIEAcellular_component
GO:0060732positive regulation of inositol phosphate biosynthIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0007187G-protein coupled receptor signaling pathway, coupTASbiological_process
GO:0004991parathyroid hormone receptor activityIEAmolecular_function
GO:0006874cellular calcium ion homeostasisIEAbiological_process
GO:0016323basolateral plasma membraneIEAcellular_component
GO:0007200phospholipase C-activating G-protein coupled recepIEAbiological_process
GO:0016324apical plasma membraneIEAcellular_component
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0002062chondrocyte differentiationIEAbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationIEAbiological_process
GO:0043621protein self-associationIDAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0045453bone resorptionIEAbiological_process
GO:0007568agingIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0001503ossificationIEAbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0007188adenylate cyclase-modulating G-protein coupled recIEAbiological_process
GO:0004888transmembrane signaling receptor activityIEAmolecular_function
GO:0007188adenylate cyclase-modulating G-protein coupled recIDAbiological_process
GO:0030282bone mineralizationIEAbiological_process
GO:0001501skeletal system developmentIEAbiological_process
GO:0017046peptide hormone bindingIDAmolecular_function
GO:0002076osteoblast developmentIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0031526brush border membraneIEAcellular_component
GO:0001501skeletal system developmentTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0008285negative regulation of cell proliferationIEAbiological_process


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